KCNE1 and CBR3

Data Source: HiPPIP (Novel)

		KCNE1	CBR3
Name		potassium voltage-gated channel subfamily E regulatory subunit 1	carbonyl reductase 3
Structure
GO Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Z Disc Monoatomic Ion Channel Complex Membrane Raft	Extracellular Space Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor NADPH Binding
	Biological Process	Epithelial Cell Maturation Monoatomic Ion Transport Potassium Ion Transport Sensory Perception Of Sound Vestibular Nucleus Development Secretory Granule Organization Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Heart Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Phase I - Functionalization of compounds
Drugs		Enflurane Promethazine Miconazole Azimilide	None
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	None
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Electrocardiographic traits (multivariate) ( 32602732 ) Hippocampal volume ( 29274321 ) L-selectin levels ( 25576479 ) Long QT syndrome ( 32429735 ) QT interval ( 24952745 29213071 30679814 31217584 )	Blood protein levels ( 30072576 ) Lumbar spine bone mineral density ( 22504420 )
Novel Interactors		3 novel interactors: CBR3 KCNJ15 RCAN1	10 novel interactors: ANK1 ATP5PO CLU IL10RB ITSN1 KCNE1 KCNJ15 PCP4 RCAN1 SHOX2
Interacting Genes		6 interacting genes: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A	7 interacting genes: ARIH2 BICD2 RAB35 RANBP9 S100A10 SDCBP UBC
Entrez ID		3753	874
HPRD ID		01442	07222
Ensembl ID		ENSG00000180509	ENSG00000159231
Uniprot IDs		A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6	O75828 V9HW40
PDB IDs		2K21	2HRB
GO Terms Enriched among Interactors		System Process Potassium Ion Import Across Plasma Membrane Muscle Contraction Muscle System Process Potassium Channel Activity Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Inorganic Cation Import Across Plasma Membrane Potassium Ion Export Across Plasma Membrane Adrenergic Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Monoatomic Ion Channel Complex Renal Sodium Ion Absorption Inward Rectifier Potassium Channel Activity Renal Sodium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Transport Membrane Repolarization Negative Regulation Of Potassium Ion Transport Regulation Of System Process Response To Mechanical Stimulus Positive Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Metal Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Import Into Cell Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Muscle Contraction Renal Absorption Regulation Of Muscle System Process Cardiac Conduction Voltage-gated Potassium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Export Across Plasma Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Cognition Regulation Of Potassium Ion Transmembrane Transport	Cytoskeletal Anchor Activity Plasma Membrane Apical Dendrite