YOD1 and UBXN6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YOD1	UBXN6
Description		YOD1 deubiquitinase	UBX domain protein 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Centrosome Cytosol Cytoskeleton Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	Protein Binding ATPase Binding
	Biological Process	Proteolysis Response To Unfolded Protein Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Response To Stress Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway
Pathways		Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Systolic blood pressure ( 28234671)	Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Multiple sclerosis ( 31604244) Red blood cell count ( 32888494)
Interacting Genes		30 interacting genes: ATG14 BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 ZFP57	21 interacting genes: APP DAZAP2 DERL1 FAM168A GSK3B MAGEA4 MCL1 NLGN3 OGT PLEKHB2 SMURF1 SUSD6 SVIP TNFAIP3 TRIM39 UBC UBXN10 UBXN2A UBXN2B VCP YOD1
Entrez ID		55432	80700
HPRD ID		10312	18253
Ensembl ID		ENSG00000180667	ENSG00000167671
Uniprot IDs		Q5VVQ6	Q9BZV1
PDB IDs		4BOQ 4BOS 4BOZ	6SAP 8FCL 8FCM 8FCN 8FCO 8FCP 8FCQ 8FCR 8FCT
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein-containing Complex Protein K48-linked Ubiquitination Zinc Ion Binding Cytoplasm Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coactivator Activity Identical Protein Binding Proteolysis Proteolysis Involved In Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Signal Transduction Nucleus Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Nuclear Body Positive Regulation Of Protein Modification Process Regulation Of Defense Response Transferase Activity Negative Regulation Of Necroptotic Process Response To Other Organism Regulation Of RIG-I Signaling Pathway Negative Regulation Of Programmed Necrotic Cell Death Protein Catabolic Process Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process	Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process ERAD Pathway Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Regulation Of Protein Modification Process Response To Endoplasmic Reticulum Stress Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of ERAD Pathway Catabolic Process Derlin-1 Retrotranslocation Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Membrane Assembly Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Endoplasmic Reticulum Unfolded Protein Response Protein K11-linked Deubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Signaling Pathway
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