YOD1 and SHARPIN

Number of citations of the paper that reports this interaction (PubMedID 28244869)
63

Data Source:
BioGRID (two hybrid)

		YOD1	SHARPIN
Description		YOD1 deubiquitinase	SHANK associated RH domain interactor
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Synapse LUBAC Complex
	Molecular Function	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Proteolysis Response To Unfolded Protein Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Mitochondrion Organization Epidermis Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Apoptotic Nuclear Changes Keratinization Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Ovarian tumor domain proteases	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Systolic blood pressure ( 28234671)	Asthma ( 31959851 32296059) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		30 interacting genes: ATG14 BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 ZFP57	30 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 PTEN RBCK1 RNF26 RNF31 SHANK1 SHANK2 SHANK3 TIAM1 TNF TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32
Entrez ID		55432	81858
HPRD ID		10312	15463
Ensembl ID		ENSG00000180667	ENSG00000179526
Uniprot IDs		Q5VVQ6	Q6PJD5 Q9H0F6
PDB IDs		4BOQ 4BOS 4BOZ	4EMO 5X0W 8K6P
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein-containing Complex Protein K48-linked Ubiquitination Zinc Ion Binding Cytoplasm Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coactivator Activity Identical Protein Binding Proteolysis Proteolysis Involved In Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Signal Transduction Nucleus Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Nuclear Body Positive Regulation Of Protein Modification Process Regulation Of Defense Response Transferase Activity Negative Regulation Of Necroptotic Process Response To Other Organism Regulation Of RIG-I Signaling Pathway Negative Regulation Of Programmed Necrotic Cell Death Protein Catabolic Process Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process	Integrin Complex Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Synaptic Receptor Adaptor Activity Cellular Extravasation Dendritic Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity Heterotypic Cell-cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Nervous System Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Social Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Signaling Receptor Activity Vocalization Behavior Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Meiotic Chromosome Movement Towards Spindle Pole Cell Adhesion Cell Surface Postsynaptic Specialization Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dopamine Metabolic Process Microglial Cell Activation LUBAC Complex Ionotropic Glutamate Receptor Binding Neuron Projection Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane RNA Strand Annealing Activity Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Positive Regulation Of Dendritic Spine Development Positive Regulation Of DNA-binding Transcription Factor Activity Postsynaptic Membrane Signal Transduction Intracellular Membraneless Organelle Regulation Of Neutrophil Degranulation
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