YOD1 and NGRN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YOD1	NGRN
Description		YOD1 deubiquitinase	neugrin, neurite outgrowth associated
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Membrane Nuclear Body Mitochondrial Membrane Intercellular Bridge Mitotic Spindle
	Molecular Function	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Deubiquitinase Activity K48-linked Deubiquitinase Activity	RNA Binding Protein Binding RRNA Binding
	Biological Process	Proteolysis Response To Unfolded Protein Macroautophagy Endoplasmic Reticulum Unfolded Protein Response Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination ERAD Pathway Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination	Cell Differentiation Neuron Differentiation Mitochondrial Ribosome Assembly Positive Regulation Of Mitochondrial Translation
Pathways		Ovarian tumor domain proteases	rRNA modification in the mitochondrion Mitochondrial mRNA modification
Drugs
Diseases
GWAS		Systolic blood pressure ( 28234671)	Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Multiple sclerosis ( 31604244)
Interacting Genes		30 interacting genes: ATG14 BIRC3 DAZAP2 DDIT4L FAM168A INCA1 LMO2 MKRN1 NEDD4 NGRN PLEKHB2 PSMA7 RFC2 RIPK1 RNF216 SHARPIN SNCA SPART TP53BP2 TRAF6 TRIM54 TRIM55 TRIM63 TRIM8 UBC UBE3A UBXN6 USP15 USP21 ZFP57	6 interacting genes: DNMT1 GTF2H5 PRKAG3 SHANK3 TSC22D2 YOD1
Entrez ID		55432	51335
HPRD ID		10312	14825
Ensembl ID		ENSG00000180667	ENSG00000182768
Uniprot IDs		Q5VVQ6	Q9NPE2
PDB IDs		4BOQ 4BOS 4BOZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Polyubiquitination Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Protein-containing Complex Protein K48-linked Ubiquitination Zinc Ion Binding Cytoplasm Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coactivator Activity Identical Protein Binding Proteolysis Proteolysis Involved In Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Signal Transduction Nucleus Defense Response To Symbiont Defense Response To Other Organism Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Nuclear Body Positive Regulation Of Protein Modification Process Regulation Of Defense Response Transferase Activity Negative Regulation Of Necroptotic Process Response To Other Organism Regulation Of RIG-I Signaling Pathway Negative Regulation Of Programmed Necrotic Cell Death Protein Catabolic Process Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Protein Modification Process	Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching DNA-methyltransferase Activity Chromosomal DNA Methylation Maintenance Following DNA Replication Regulation Of Phenotypic Switching Germ Cell Nucleus Cellular Response To Bisphenol A DNA (cytosine-5-)-methyltransferase Activity Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Carbon Utilization Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination Protein K27-linked Deubiquitination Guanylate Kinase-associated Protein Clustering Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Striatal Medium Spiny Neuron Differentiation Nucleotide-excision Repair, Preincision Complex Assembly Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A AMP-activated Protein Kinase Activity Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Transcription Elongation By RNA Polymerase I Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Nucleotide-activated Protein Kinase Complex Negative Regulation Of Glycogen Biosynthetic Process AMP Binding Negative Regulation Of Protein Exit From Endoplasmic Reticulum Protein K11-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Vocal Learning Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Postsynaptic Specialization Assembly Transcription Factor TFIIH Core Complex Female Germ Cell Nucleus Regulation Of Retrograde Protein Transport, ER To Cytosol Neurotransmitter-gated Ion Channel Clustering Transcription Factor TFIIH Holo Complex Auditory Behavior Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Long-term Synaptic Depression Protein Kinase Regulator Activity
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