CEP55 and PTPN23

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CEP55	PTPN23
Description		centrosomal protein 55	protein tyrosine phosphatase non-receptor type 23
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytoskeleton Membrane Midbody Cleavage Furrow Intercellular Bridge Flemming Body	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Cilium Nuclear Body Cytoplasmic Vesicle Centriolar Satellite Ciliary Basal Body Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Chromosome Alignment Establishment Of Protein Localization Cell Division Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Midbody Abscission Cranial Skeletal System Development	Negative Regulation Of Epithelial Cell Migration Protein Transport Cell Projection Organization Endocytic Recycling Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Early Endosome To Late Endosome Transport Cilium Assembly Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Homophilic Cell Adhesion Positive Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways			Interleukin-37 signaling
Drugs
Diseases
GWAS		High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)	C-reactive protein levels ( 30388399) Refractive error ( 32231278) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		94 interacting genes: AIRIM AKAP9 ANXA11 ARHGEF15 BAG4 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 CFTR COL8A1 CPSF7 DTNB ECSIT EIF1AD ENKD1 ESS2 EXOSC5 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HNRNPA0 HSF2BP KANK2 KIFC3 KRT31 LENG1 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NEDD4L NOS3 NTAQ1 NXF1 OGT PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PRPF6 PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RBM42 RBPMS RCOR3 RNF32 SDCBP SF1 SFPQ SNRPB SNRPN SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TFG TFIP11 TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48	12 interacting genes: ALG2 BICD1 CEP19 CEP55 CHMP4B DDX24 LRRK2 NOTCH2NLA PSMA3 TRIM27 UBAP1 WDR4
Entrez ID		55165	25930
HPRD ID		12569	05959
Ensembl ID		ENSG00000138180	ENSG00000076201
Uniprot IDs		Q53EZ4	B4DST5 Q9H3S7
PDB IDs		3E1R 3WUT 3WUU 3WUV	3RAU 5CRU 5CRV 5LM1 5LM2 5MJY 5MJZ 5MK0 5MK1 5MK2 5MK3
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Binding Spliceosomal Complex Centrosome MRNA Processing Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway RNA Splicing Nucleoplasm MRNA Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Catalytic Step 2 Spliceosome Cytoskeleton Multivesicular Body Assembly Multivesicular Body Organization Positive Regulation Of Exosomal Secretion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway RNA Processing Calcium-dependent Protein Binding RNA Binding Viral Budding Via Host ESCRT Complex Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Viral Budding MRNA Binding Protein Localization To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Component Assembly Nucleic Acid Metabolic Process Microtubule Nucleation Cytosol Establishment Of Protein Localization To Vacuole ESCRT I Complex Centriole Cytoplasm Spindle Nucleic Acid Binding U4/U6 X U5 Tri-snRNP Complex Microtubule Cytoskeleton Organization Involved In Mitosis MRNA Cis Splicing, Via Spliceosome SnRNP Binding Endosome Organization Microtubule Organizing Center Organization Membrane Fission Microtubule-based Process Organelle Assembly	Organelle Localization Microtubule Anchoring Microtubule Anchoring At Microtubule Organizing Center Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Organization Mitotic Cytokinetic Process Midbody Abscission Late Endosome To Vacuole Transport Vesicle-mediated Transport Intracellular Transport Endosomal Transport Membrane Organization Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Metaphase Chromosome Alignment Cytokinetic Process Mitotic Metaphase Chromosome Alignment Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Negative Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Organelle Assembly Endosome TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex Mitotic Cytokinesis Chromosome Localization Alpha-1,3-mannosyltransferase Activity Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Endosome Organization Establishment Of Protein Localization To Organelle Proteinase Activated Receptor Binding Negative Regulation Of Catabolic Process TRNA (guanine-N7)-methylation Cytoskeleton-dependent Cytokinesis Nucleus Organization Regulation Of Notch Signaling Pathway Positive Regulation Of Protein Autoubiquitination Response To Curcumin
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