CEP55 and NOS3

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		CEP55	NOS3
Gene Name		centrosomal protein 55kDa	nitric oxide synthase 3 (endothelial cell)
Image
Gene Ontology Annotations	Cellular Component	Centrosome Centriole Membrane Midbody Cleavage Furrow Intercellular Bridge	Golgi Membrane Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Caveola Endocytic Vesicle Membrane
	Molecular Function	Protein Binding	Actin Monomer Binding NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Mitotic Cytokinesis Cell Separation After Cytokinesis Nucleus Organization Mitotic Metaphase Plate Congression Establishment Of Protein Localization	Angiogenesis Ovulation From Ovarian Follicle In Utero Embryonic Development Blood Vessel Remodeling Regulation Of Sodium Ion Transport Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Arginine Catabolic Process Nitric Oxide Biosynthetic Process Mitochondrion Organization Nitric Oxide Mediated Signal Transduction Blood Coagulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Heat Negative Regulation Of Platelet Activation Negative Regulation Of Muscle Hyperplasia Smooth Muscle Hyperplasia Lung Development Positive Regulation Of Guanylate Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Fluid Shear Stress Negative Regulation Of Potassium Ion Transport Endothelial Cell Migration Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Hydrolase Activity Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Phagosome Maturation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Phagosomal maturation (early endosomal stage) VEGFA-VEGFR2 Pathway eNOS activation Metabolism of nitric oxide Platelet homeostasis Signaling by VEGF VEGFR2 mediated vascular permeability NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Latent infection of Homo sapiens with Mycobacterium tuberculosis Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase eNOS activation and regulation
Drugs			L-Arginine L-Citrulline Tetrahydrobiopterin Miconazole N,N-dimethylarginine L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide L-2-Amino-4-(Guanidinooxy)Butyric Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine 1,2,4-Triazole-Carboxamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide S,S\'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Hydroxydimethylarsine Oxide Heme 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N-Omega-Hydroxy-L-Arginine N5-Iminoethyl-L-Ornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S\'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6s-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-Homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N\'-Hydroxyguanidine (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine
Diseases
GWAS
Protein-Protein Interactions		55 interactors: AKAP9 ANXA11 ARHGEF15 C1orf109 CCBE1 CCDC53 CCHCR1 CDC45 CDK1 CDSN CEP57L1 DTNB ECSIT EIF1AD FAM90A1 FBF1 FXR2 GOLGA8DP HAUS1 HGS KIFC3 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 MUM1 NOS3 PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PSEN2 PTPN23 RAB3D RBM17 RBM22 RCOR3 RNF32 SDCBP SNRPB SNW1 SSX2IP TCL1A TEAD4 TEX14 TFG TSG101 VPS37C VPS37D	46 interactors: A2M ACTN2 ACTN4 AGTR1 AKT1 APOE APP BDKRB2 BDNF CALM1 CAV1 CDC37 CEP55 EDNRB EFEMP1 EFEMP2 ELAVL1 ELAVL3 EXOC6 EXOSC1 FIS1 GCDH GOLGA2 H3F3A HSP90AA1 HTRA1 IMMT KANK2 MAGEA11 MAST1 MPRIP NMT1 NOSIP NOSTRIN PAXIP1 PI4K2A PPP2R5A PSEN1 PSEN2 RNF31 RNF32 SP1 ST13 TECR TXNDC11 UMPS
Entrez ID		55165	4846
HPRD ID		12569	01224
Ensembl ID		ENSG00000138180	ENSG00000164867
Uniprot IDs		Q53EZ4	A0S0A6 P29474
PDB IDs		3E1R	1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 2LL7 3EAH 3NOS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Localization Establishment Of Protein Localization Virion Assembly Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Exocytosis Protein Transport Viral Protein Processing Positive Regulation Of Transport Mitotic Cell Cycle Process Regulation Of Vesicle-mediated Transport Cell Cycle Regulation Of Exocytosis Mitotic Cell Cycle Organelle Organization Cell Division Microtubule Cytoskeleton Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Intracellular Transport Of Virus Cell Cycle Process Regulation Of Cellular Localization Viral Life Cycle Centrosome Organization Membrane Organization Cellular Localization Mitotic Nuclear Envelope Disassembly Positive Regulation Of Metabolic Process Microtubule Organizing Center Organization Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Anatomical Structure Development Nuclear Envelope Disassembly G2/M Transition Of Mitotic Cell Cycle Viral Process Microtubule-based Process Viral Budding Developmental Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Anatomical Structure Morphogenesis Cell Differentiation Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Cell Projection Morphogenesis Regulation Of Early Endosome To Late Endosome Transport Cellular Protein Localization Cell Part Morphogenesis Regulation Of Cellular Component Organization Nuclear Envelope Organization	Regulation Of Nitric-oxide Synthase Activity Regulation Of Oxidoreductase Activity Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Secretion Cellular Metal Ion Homeostasis Regulation Of Cellular Protein Metabolic Process Cellular Cation Homeostasis Regulation Of Body Fluid Levels Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Regulation Of Cellular Amino Acid Metabolic Process Cellular Homeostasis Response To Abiotic Stimulus Ion Homeostasis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation Homeostatic Process Hemostasis Reactive Oxygen Species Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Exocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Platelet Degranulation Regulation Of Blood Vessel Size Secretion By Cell Chemical Homeostasis Regulation Of Tube Size Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Response To Wounding Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ion Transport Wound Healing Establishment Of Localization In Cell Signaling Signal Transduction Negative Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Ion Transport Regulation Of Catalytic Activity Cell Communication Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		atad2 birc5 cdkn2a cldn6 crypt ct26 epcam flt1 g12d gp70 hif1a homozygously immunome immunotherapies mabs mhc mki67 ms4a8a ms4a8b muc2 mutated nras pbk syngeneic synonymous top2a transcriptome trp53 undifferentiated	antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal
Tagcloud (Difference) ?		atad2 birc5 cdkn2a cldn6 crypt ct26 epcam flt1 g12d gp70 hif1a homozygously immunome immunotherapies mabs mhc mki67 ms4a8a ms4a8b muc2 mutated nras pbk syngeneic synonymous top2a transcriptome trp53 undifferentiated	antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal
Tagcloud (Intersection) ?