TNNT1 and TBPL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TNNT1	TBPL1
Description		troponin T1, slow skeletal type	TATA-box binding protein like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm
	Molecular Function	Protein Binding Tropomyosin Binding Troponin T Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity General Transcription Initiation Factor Activity
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Transition Between Fast And Slow Fiber Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Negative Regulation Of Muscle Contraction	Acrosome Assembly DTTP Biosynthetic Process DNA-templated Transcription Initiation Transcription By RNA Polymerase II Spermatogenesis Spermatid Nucleus Differentiation Nucleobase-containing Compound Biosynthetic Process
Pathways		Striated Muscle Contraction
Drugs
Diseases		Nemaline myopathy
GWAS		Height ( 31562340)	Height ( 28552196) Night sleep phenotypes ( 27126917)
Interacting Genes		69 interacting genes: ARMC8 BLOC1S2 BMPR1B CCDC136 CCDC85B CHD3 CLIP4 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HSP90AB1 IMMT KAT5 KRT27 KRT40 LARP1 LDOC1 MARS1 MORF4L1 MYOM2 NACAD NAGK NFE2L2 NINL NSG2 OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SBK3 SDCBP2 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TNNT2 TPM1 TPM3 TRA2A TRIM63 TSPYL2 TULP3 UBE2D1 VIM WDCP ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	18 interacting genes: ABCF3 APP DVL3 FBXO7 GTF2A1 GTF2A2 GTF2B IRAK4 LSM5 NDUFA6 NF1 PLIN3 PRNP PTCD3 RAB35 RPL10 SLC35F6 TNNT1
Entrez ID		7138	9519
HPRD ID		01841	09272
Ensembl ID		ENSG00000105048	ENSG00000028839
Uniprot IDs		P13805	P62380
PDB IDs
Enriched GO Terms of Interacting Partners?		Troponin Complex Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Muscle System Process Cardiac Troponin Complex Cardiac Muscle Tissue Morphogenesis Muscle Contraction Troponin T Binding Muscle Filament Sliding I-SMAD Binding Muscle Tissue Morphogenesis Actin-myosin Filament Sliding Striated Muscle Contraction Protein Binding Skeletal Muscle Contraction Primary MiRNA Processing Homomeric SMAD Protein Complex Actin-mediated Cell Contraction Contractile Muscle Fiber Regulation Of Hematopoietic Stem Cell Differentiation Tissue Morphogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Troponin C Binding Regulation Of Muscle System Process Regulation Of Muscle Contraction Sarcomere Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Troponin I Binding Muscle Thin Filament Tropomyosin Cytosol Actin Filament-based Movement Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytoskeleton Organization Transforming Growth Factor Beta Receptor Activity, Type I Disordered Domain Specific Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process R-SMAD Binding Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Stem Cell Differentiation Calcium-dependent Protein Binding SMAD Protein Complex Trophoblast Cell Migration Transition Between Fast And Slow Fiber Cardiac Myofibril	Regulation Of Long-term Synaptic Potentiation Cytosol TBP-class Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIIA Complex Transcription Factor TFIID Complex Protein Heterodimerization Activity RNA Polymerase II Preinitiation Complex Assembly RNA Polymerase II General Transcription Initiation Factor Binding Transcription Initiation At RNA Polymerase II Promoter Transcription Preinitiation Complex Assembly Positive Regulation Of Neuron Apoptotic Process Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Transcription Preinitiation Complex DNA-templated Transcription Initiation Regulation Of Neuron Apoptotic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cellular Response To Copper Ion Molecular Function Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Response To Copper Ion Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Signaling Pathway Frizzled Binding Cellular Response To Nerve Growth Factor Stimulus Protein-DNA Complex Assembly Transcriptional Start Site Selection At RNA Polymerase II Promoter Positive Regulation Of Mast Cell Apoptotic Process Type 8 Metabotropic Glutamate Receptor Binding Slow-twitch Skeletal Muscle Fiber Contraction Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Plasticity Cellular Response To Amyloid-beta Protein-containing Complex Assembly Regulation Of Amyloid Precursor Protein Catabolic Process
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