TNNT1 and TPM1

Number of citations of the paper that reports this interaction (PMID 6822572)
24

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro)

		TNNT1	TPM1
Gene Name		troponin T type 1 (skeletal, slow)	tropomyosin 1 (alpha)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Sarcomere Filamentous Actin Bleb Ruffle Membrane
	Molecular Function	Tropomyosin Binding Troponin T Binding	Actin Binding Structural Constituent Of Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Muscle
	Biological Process	Skeletal Muscle Contraction Muscle Filament Sliding Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Muscle Contraction	In Utero Embryonic Development Positive Regulation Of Heart Rate By Epinephrine Movement Of Cell Or Subcellular Component Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS			Mean platelet volume ( 19820697) Orofacial clefts ( 22863734) Platelet counts ( 22139419)
Protein-Protein Interactions		61 interactors: ARMC8 BLOC1S2 BMPR1B C2orf44 CCDC136 CCDC85B CHD3 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HMP19 HSP90AB1 IMMT KAT5 KRT40 LARP1 LDOC1 MARS MORF4L1 NACAD NAGK NFE2L2 NINL OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TPM1 TPM3 TRA2A TRIM63 UBE2D1 VIM ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	18 interactors: ACTB C1orf216 CAGE1 EGFR EPB41 GOLGA2 JUN KXD1 MAD1L1 PKD2 S100A2 SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4
Entrez ID		7138	7168
HPRD ID		01841	01839
Ensembl ID		ENSG00000105048	ENSG00000140416
Uniprot IDs		P13805	B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H7BYY1 O15513 P09493 Q6ZN40
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle System Process Regulation Of Metabolic Process Muscle Contraction Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Muscle Contraction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component Ventricular Cardiac Muscle Tissue Development Regulation Of Cellular Process Cardiac Muscle Tissue Morphogenesis Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Cellular Response To Organic Substance Muscle Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Regulation Of RNA Metabolic Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cellular Macromolecule Biosynthetic Process BMP Signaling Pathway Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Signaling Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Striated Muscle Contraction Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Transforming Growth Factor Beta Stimulus RNA Metabolic Process RNA Biosynthetic Process Response To Transforming Growth Factor Beta Cardiac Muscle Tissue Development Primary MiRNA Processing Cellular Response To Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Signaling Pathway Response To Stimulus	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Actin Filament-based Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Response To Calcium Ion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Liver Development Immune Response-regulating Signaling Pathway Response To Inorganic Substance Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ATPase Activity Negative Regulation Of Mitotic Cell Cycle Response To Mechanical Stimulus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Heart Morphogenesis Organelle Organization Regulation Of Binding Positive Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Regulation Of Nitric Oxide Biosynthetic Process Alkanesulfonate Metabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Metaphase Plate Congression Cellular Response To Potassium Ion Starvation Fc Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Epithelial Cell Proliferation Cognition Positive Regulation Of DNA Replication Mitotic Cell Cycle Response To Metal Ion Myofibril Assembly Protein Kinase D Signaling Leading Edge Cell Differentiation Metanephric Smooth Muscle Tissue Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Detection Of Nodal Flow Astrocyte Activation Renal Artery Morphogenesis
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39	abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39	abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable
Tagcloud (Intersection) ?