TNNT1 and OSBP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TNNT1	OSBP2
Gene Name		troponin T type 1 (skeletal, slow)	oxysterol binding protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	Membrane
	Molecular Function	Tropomyosin Binding Troponin T Binding	Cholesterol Binding
	Biological Process	Skeletal Muscle Contraction Muscle Filament Sliding Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Muscle Contraction	Lipid Transport
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065)
Protein-Protein Interactions		61 interactors: ARMC8 BLOC1S2 BMPR1B C2orf44 CCDC136 CCDC85B CHD3 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HMP19 HSP90AB1 IMMT KAT5 KRT40 LARP1 LDOC1 MARS MORF4L1 NACAD NAGK NFE2L2 NINL OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TPM1 TPM3 TRA2A TRIM63 UBE2D1 VIM ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	3 interactors: LNX1 TNNT1 VIM
Entrez ID		7138	23762
HPRD ID		01841	09471
Ensembl ID		ENSG00000105048	ENSG00000184792
Uniprot IDs		P13805	B4DFA8 Q969R2
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle System Process Regulation Of Metabolic Process Muscle Contraction Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Muscle Contraction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component Ventricular Cardiac Muscle Tissue Development Regulation Of Cellular Process Cardiac Muscle Tissue Morphogenesis Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Cellular Response To Organic Substance Muscle Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Regulation Of RNA Metabolic Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cellular Macromolecule Biosynthetic Process BMP Signaling Pathway Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Signaling Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Striated Muscle Contraction Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Transforming Growth Factor Beta Stimulus RNA Metabolic Process RNA Biosynthetic Process Response To Transforming Growth Factor Beta Cardiac Muscle Tissue Development Primary MiRNA Processing Cellular Response To Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Signaling Pathway Response To Stimulus	Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Slow-twitch Skeletal Muscle Fiber Contraction Bergmann Glial Cell Differentiation Actin Filament-based Process Intermediate Filament Organization Lens Fiber Cell Development Negative Regulation Of Muscle Contraction Astrocyte Development Skeletal Muscle Contraction Lens Fiber Cell Differentiation Intermediate Filament Cytoskeleton Organization Astrocyte Differentiation Musculoskeletal Movement Intermediate Filament-based Process SMAD Protein Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Striated Muscle Contraction Movement Of Cell Or Subcellular Component Lens Development In Camera-type Eye Glial Cell Development
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39	7d 9d abcc10 arginyltransferase ate1 cd226 chicks crna defocus diffusers e74 elf1 emmetropization erythrocytic genechip leghorn lenses myopic oxysterol prepro rma shq1 spectacle spectrin sptbn1 urotensin urp wore worn
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39	7d 9d abcc10 arginyltransferase ate1 cd226 chicks crna defocus diffusers e74 elf1 emmetropization erythrocytic genechip leghorn lenses myopic oxysterol prepro rma shq1 spectacle spectrin sptbn1 urotensin urp wore worn
Tagcloud (Intersection) ?