TNNT1 and HMGXB4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TNNT1	HMGXB4
Gene Name		troponin T type 1 (skeletal, slow)	HMG box domain containing 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	NURF Complex
	Molecular Function	Tropomyosin Binding Troponin T Binding	DNA Binding Chromatin Binding
	Biological Process	Skeletal Muscle Contraction Muscle Filament Sliding Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Muscle Contraction	Chromatin Remodeling Regulation Of Transcription, DNA-templated Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARMC8 BLOC1S2 BMPR1B C2orf44 CCDC136 CCDC85B CHD3 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HMP19 HSP90AB1 IMMT KAT5 KRT40 LARP1 LDOC1 MARS MORF4L1 NACAD NAGK NFE2L2 NINL OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TPM1 TPM3 TRA2A TRIM63 UBE2D1 VIM ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	7 interactors: HABP4 HIST3H3 JMJD6 NR1H2 TNNT1 TSC22D1 UROD
Entrez ID		7138	10042
HPRD ID		01841	05267
Ensembl ID		ENSG00000105048	ENSG00000100281
Uniprot IDs		P13805	Q7Z641 Q9UGU5
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle System Process Regulation Of Metabolic Process Muscle Contraction Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Muscle Contraction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component Ventricular Cardiac Muscle Tissue Development Regulation Of Cellular Process Cardiac Muscle Tissue Morphogenesis Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Cellular Response To Organic Substance Muscle Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Regulation Of RNA Metabolic Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cellular Macromolecule Biosynthetic Process BMP Signaling Pathway Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Signaling Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Striated Muscle Contraction Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Transforming Growth Factor Beta Stimulus RNA Metabolic Process RNA Biosynthetic Process Response To Transforming Growth Factor Beta Cardiac Muscle Tissue Development Primary MiRNA Processing Cellular Response To Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Signaling Pathway Response To Stimulus	Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Nitrogen Compound Metabolic Process Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Cholesterol Storage Recognition Of Apoptotic Cell Transcription, DNA-templated Positive Regulation Of Digestive System Process Protoporphyrinogen IX Biosynthetic Process RNA Biosynthetic Process Protoporphyrinogen IX Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Cholesterol Homeostasis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Phagocytosis, Recognition Biosynthetic Process Homeostatic Process Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Muscle Contraction Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process Skeletal Muscle Contraction Heme Biosynthetic Process Protein Hydroxylation Macrophage Activation Positive Regulation Of Lipid Storage Actin-myosin Filament Sliding Positive Regulation Of Fatty Acid Metabolic Process Apoptotic Cell Clearance Muscle Filament Sliding
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39
Tagcloud (Intersection) ?