TNNT1 and NACAD

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TNNT1	NACAD
Description		troponin T1, slow skeletal type	NAC alpha domain containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Nucleus Cytoplasm Nascent Polypeptide-associated Complex
	Molecular Function	Protein Binding Tropomyosin Binding Troponin T Binding	Protein Binding Unfolded Protein Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Transition Between Fast And Slow Fiber Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Negative Regulation Of Muscle Contraction	Protein Targeting To Membrane Protein Transport
Pathways		Striated Muscle Contraction
Drugs
Diseases		Nemaline myopathy
GWAS		Height ( 31562340)	Eosinophil count ( 32888494)
Interacting Genes		69 interacting genes: ARMC8 BLOC1S2 BMPR1B CCDC136 CCDC85B CHD3 CLIP4 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HSP90AB1 IMMT KAT5 KRT27 KRT40 LARP1 LDOC1 MARS1 MORF4L1 MYOM2 NACAD NAGK NFE2L2 NINL NSG2 OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SBK3 SDCBP2 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TNNT2 TPM1 TPM3 TRA2A TRIM63 TSPYL2 TULP3 UBE2D1 VIM WDCP ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	10 interacting genes: AGTR1 CBLC HDAC6 MAP4K2 NR4A1 PTK2 RPS27 STAT3 TNNT1 YAE1
Entrez ID		7138	23148
HPRD ID		01841
Ensembl ID		ENSG00000105048	ENSG00000136274
Uniprot IDs		P13805	O15069
PDB IDs
Enriched GO Terms of Interacting Partners?		Troponin Complex Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Muscle System Process Cardiac Troponin Complex Cardiac Muscle Tissue Morphogenesis Muscle Contraction Troponin T Binding Muscle Filament Sliding I-SMAD Binding Muscle Tissue Morphogenesis Actin-myosin Filament Sliding Striated Muscle Contraction Protein Binding Skeletal Muscle Contraction Primary MiRNA Processing Homomeric SMAD Protein Complex Actin-mediated Cell Contraction Contractile Muscle Fiber Regulation Of Hematopoietic Stem Cell Differentiation Tissue Morphogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Troponin C Binding Regulation Of Muscle System Process Regulation Of Muscle Contraction Sarcomere Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Troponin I Binding Muscle Thin Filament Tropomyosin Cytosol Actin Filament-based Movement Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytoskeleton Organization Transforming Growth Factor Beta Receptor Activity, Type I Disordered Domain Specific Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process R-SMAD Binding Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Stem Cell Differentiation Calcium-dependent Protein Binding SMAD Protein Complex Trophoblast Cell Migration Transition Between Fast And Slow Fiber Cardiac Myofibril	Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Endothelial Cell Proliferation Nuclear Glucocorticoid Receptor Binding Regulation Of Epithelial Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Endothelial Cell Proliferation Growth Hormone Receptor Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Protein-containing Complex Organization Bradykinin Receptor Binding Positive Regulation Of Cell Differentiation Macromolecule Metabolic Process Establishment Of Protein Localization To Organelle Nuclear Receptor Activity Cellular Response To Hormone Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Epithelial Cell Migration ERBB Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Phosphorylation Protein Phosphatase Binding Regulation Of Cell Population Proliferation Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Tubulin Deacetylation Positive Regulation Of Response To Oxidative Stress Regulation Of Cholangiocyte Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Angiotensin Type II Receptor Activity
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