TNNT1 and HSP90AB1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TNNT1	HSP90AB1
Gene Name		troponin T type 1 (skeletal, slow)	heat shock protein 90kDa alpha (cytosolic), class B member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol COP9 Signalosome Cell Surface Membrane Inclusion Body Basolateral Plasma Membrane Apical Plasma Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Tropomyosin Binding Troponin T Binding	UTP Binding CTP Binding Double-stranded RNA Binding Protein Binding ATP Binding GTP Binding Sulfonylurea Receptor Binding Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding DATP Binding Ion Channel Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Skeletal Muscle Contraction Muscle Filament Sliding Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Muscle Contraction	Placenta Development Protein Folding Response To Unfolded Protein Axon Guidance Response To Salt Stress Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Heat Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Size Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-4 Cellular Response To Organic Cyclic Compound Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways		Striated Muscle Contraction	HSF1 activation Axon guidance Semaphorin interactions Inflammasomes Attenuation phase Cellular response to heat stress HSF1-dependent transactivation Uptake and actions of bacterial toxins The NLRP3 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Sema3A PAK dependent Axon repulsion Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Uptake and function of diphtheria toxin Innate Immune System
Drugs			Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Adenosine-5\'-Diphosphate Radicicol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS
Protein-Protein Interactions		61 interactors: ARMC8 BLOC1S2 BMPR1B C2orf44 CCDC136 CCDC85B CHD3 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HMP19 HSP90AB1 IMMT KAT5 KRT40 LARP1 LDOC1 MARS MORF4L1 NACAD NAGK NFE2L2 NINL OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TPM1 TPM3 TRA2A TRIM63 UBE2D1 VIM ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	41 interactors: ACD AKT1 ARHGAP1 CCT2 CDC37L1 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 ESR1 FCHSD2 HIF1A IKBKB IKBKE IKBKG MAP3K14 MAP3K3 MAPK6 MKNK1 NR2C2 NR4A1 POT1 PPID SGTA SLC34A1 STARD13 STAT1 STAT3 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 USP50 WASL YWHAB
Entrez ID		7138	3326
HPRD ID		01841	06763
Ensembl ID		ENSG00000105048	ENSG00000096384
Uniprot IDs		P13805	B4DGL0 P08238 Q6PK50
PDB IDs			1QZ2 1UYM 3NMQ 3PRY
Enriched GO Terms of Interacting Partners?		Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle System Process Regulation Of Metabolic Process Muscle Contraction Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Muscle Contraction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component Ventricular Cardiac Muscle Tissue Development Regulation Of Cellular Process Cardiac Muscle Tissue Morphogenesis Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Cellular Response To Organic Substance Muscle Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Regulation Of RNA Metabolic Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cellular Macromolecule Biosynthetic Process BMP Signaling Pathway Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Signaling Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Striated Muscle Contraction Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Transforming Growth Factor Beta Stimulus RNA Metabolic Process RNA Biosynthetic Process Response To Transforming Growth Factor Beta Cardiac Muscle Tissue Development Primary MiRNA Processing Cellular Response To Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Signaling Pathway Response To Stimulus	Positive Regulation Of Signal Transduction Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Cellular Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of DNA Replication Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Telomere Maintenance Cellular Response To Stimulus Apoptotic Process Telomere Assembly Programmed Cell Death Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Death Death Regulation Of Cell Death Regulation Of Immune System Process MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Signaling Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Transcription, DNA-templated Phosphorylation Homeostatic Process Regulation Of Organelle Organization Toll-like Receptor 4 Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Negative Regulation Of Chromosome Organization Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Positive Regulation Of Gene Expression Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Difference) ?		apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39	1as atg aurothioglucose bpd bronchopulmonary bso buthionine comparatively cysteines cytoprotection h1299 hyperoxia hyperoxic nitrosylation oxidoreductase peroxiredoxin pharmacologically redox relies simplification smallest sulfoximine thiol thioredoxin trx trx1 vasculature
Tagcloud (Intersection) ?