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TRPC4AP and TNFRSF1A
Number of citations of the paper that reports this interaction (PMID
14585990
)
6
Data Source:
HPRD
(in vivo)
TRPC4AP
TNFRSF1A
Gene Name
transient receptor potential cation channel, subfamily C, member 4 associated protein
tumor necrosis factor receptor superfamily, member 1A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Cul4A-RING E3 Ubiquitin Ligase Complex
Golgi Membrane
Extracellular Region
Extracellular Space
Nucleus
Mitochondrion
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Axon
Receptor Complex
Membrane Raft
Synapse
Molecular Function
Protein Binding
Phosphatase Binding
Protease Binding
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Protein Complex Binding
Tumor Necrosis Factor Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Ion Transmembrane Transport
Transmembrane Transport
Calcium Ion Transmembrane Transport
Response To Hypoxia
Prostaglandin Metabolic Process
Inflammatory Response
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Wounding
Negative Regulation Of Gene Expression
Viral Process
Cytokine-mediated Signaling Pathway
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Tetrapyrrole Metabolic Process
Positive Regulation Of Protein Import Into Nucleus, Translocation
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Response To Alkaloid
Positive Regulation Of Neuron Apoptotic Process
Response To Ethanol
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Protein Heterooligomerization
Cellular Response To Mechanical Stimulus
Cellular Response To Estradiol Stimulus
Apoptotic Signaling Pathway
Pathways
Ion channel transport
TRP channels
Stimuli-sensing channels
TNF signaling
Death Receptor Signalling
Programmed Cell Death
Extrinsic Pathway
Drugs
6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS
Prothrombin time (
22703881
)
Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) (
23648065
)
Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) (
23648065
)
Multiple sclerosis (
19525953
21833088
)
Primary biliary cirrhosis (
21399635
)
Protein-Protein Interactions
9 interactors:
CHMP4C
CHUK
IKBKB
IKBKG
RIPK1
TAB1
TNFRSF1A
TRADD
TRAF2
60 interactors:
ADAM17
ATF6
BAG4
BCL10
CASP10
CASP7
CHUK
CLIP3
DAPK1
DAXX
ERAP1
ERN1
FANCD2
GNB2L1
GRB2
GYS2
HRG
HSP90AA1
HSPA8
IKBKB
IKBKG
JAK1
JAK2
LTA
LTB
MADD
MAGEH1
MAPK1
MOAP1
MYOC
NSMAF
PIP4K2B
PRDX3
PRKCD
PSMD2
PTK2
PTPN11
PTPN6
RASSF1
RIPK1
RIPK2
RIPK3
SGTA
SRC
STAMBP
STAT1
SUMO1
SYK
TNF
TNFRSF25
TNFSF13
TRADD
TRAF1
TRAF2
TRAF3
TRAP1
TRPC4AP
UBE2I
UBQLN1
UCHL1
Entrez ID
26133
7132
HPRD ID
09238
01861
Ensembl ID
ENSG00000100991
ENSG00000067182
Uniprot IDs
B4E0Q1
E1P5Q0
Q8TEL6
J9PH39
P19438
PDB IDs
1EXT
1FT4
1ICH
1NCF
1TNR
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of NF-kappaB Transcription Factor Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Tumor Necrosis Factor
Toll-like Receptor Signaling Pathway
Response To Tumor Necrosis Factor
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Activation Of Innate Immune Response
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Innate Immune Response
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Innate Immune Response
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Signal Transduction
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Cytokine Production
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Immune Response-regulating Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of Intracellular Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Cytokine Production
Positive Regulation Of Type I Interferon Production
Cellular Response To Cytokine Stimulus
Positive Regulation Of Immune Response
Regulation Of Type I Interferon Production
Response To Cytokine
Defense Response
Protein Heterooligomerization
Innate Immune Response
Positive Regulation Of Cellular Metabolic Process
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Signal Transduction
Intracellular Receptor Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Signaling
Apoptotic Process
Regulation Of Apoptotic Process
Programmed Cell Death
Regulation Of Cell Death
Cell Death
Death
Regulation Of Signal Transduction
Regulation Of Immune Response
Positive Regulation Of Signal Transduction
Positive Regulation Of Protein Metabolic Process
Regulation Of Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Immune Response
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Innate Immune Response
Innate Immune Response
Response To Stress
Regulation Of Immune System Process
Regulation Of Phosphorylation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Stimulus
Cellular Response To Stimulus
Positive Regulation Of Protein Modification Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Cell Communication
Regulation Of Phosphorus Metabolic Process
Defense Response
Positive Regulation Of Immune Response
Immune System Process
Signal Transduction
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Signaling
Regulation Of Kinase Activity
Positive Regulation Of Immune System Process
Regulation Of Protein Phosphorylation
Response To Organic Substance
Regulation Of Protein Kinase Activity
Regulation Of Catalytic Activity
Immune Response-regulating Signaling Pathway
Positive Regulation Of Transferase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Response To Cytokine
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Phosphorylation
Tagcloud
?
casp3
cl
coincided
corpora
cyclic
disaggregation
estrous
extrinsic
fas
fasl
faslg
fos
ifng
ifngamma
jun
lutea
luteal
luteolysis
luteolytic
p4
pgf2alpha
postmortem
pregnancy
proportions
tnfa
tnfr2
viable
Tagcloud (Difference)
?
casp3
cl
coincided
corpora
cyclic
disaggregation
estrous
extrinsic
fas
fasl
faslg
fos
ifng
ifngamma
jun
lutea
luteal
luteolysis
luteolytic
p4
pgf2alpha
postmortem
pregnancy
proportions
tnfa
tnfr2
viable
Tagcloud (Intersection)
?