ATF6 and ATF6B

Number of citations of the paper that reports this interaction (PubMedID 11158310)
28

Data Source:
HPRD (in vitro)

		ATF6	ATF6B
Description		activating transcription factor 6	activating transcription factor 6 beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane RNA Polymerase II Transcription Regulator Complex	Golgi Membrane Chromatin Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response ERAD Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ATF6-mediated Unfolded Protein Response	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of ATF6-mediated Unfolded Protein Response
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Modulation of host responses by IFN-stimulated genes	ATF6B (ATF6-beta) activates chaperones ATF6B (ATF6-beta) activates chaperones
Drugs		Pseudoephedrine
Diseases
GWAS		Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Severe insulin-deficient type 2 diabetes ( 34737425) Systemic sclerosis ( 30247649)	A body shape index ( 34021172) Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 32469254) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		18 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT RNF168 SRF TNFRSF1A UBASH3A XBP1 YY1	10 interacting genes: ATF6 CDK6 CREBZF LHX8 MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1
Entrez ID		22926	1388
HPRD ID		16118	02992
Ensembl ID		ENSG00000118217	ENSG00000213676
Uniprot IDs		A0A7P0TAF2 A0A7P0Z421 A8K383 P18850	A0A1U9X796 Q6AZW6 Q99941
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process CCAAT-binding Factor Complex DNA Binding Regulation Of Gene Expression Protein-DNA Complex Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Peptide Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process ATF6-mediated Unfolded Protein Response Hemopoiesis Regulation Of Metabolic Process Myeloid Cell Development Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of MiRNA Transcription Response To Stress Nucleobase-containing Compound Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Stress Nucleoplasm Response To Unfolded Protein Regulation Of MiRNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Regulation Of Cellular Response To Stress	ATF6-mediated Unfolded Protein Response ER-nucleus Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Transcription Regulator Complex Response To Endoplasmic Reticulum Stress Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process CCAAT-binding Factor Complex Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of G2/M Transition Of Mitotic Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Lipid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process NLS-bearing Protein Import Into Nucleus Cellular Response To Stress Neuron Development Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Regulation Of Lipid Biosynthetic Process Membrane Protein Proteolysis Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Steroid Biosynthetic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Macromolecule Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress
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