TSPAN4 and ITGA6

Number of citations of the paper that reports this interaction (PMID 9360996)
17

Data Source:
HPRD (in vivo)

		TSPAN4	ITGA6
Gene Name		tetraspanin 4	integrin, alpha 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integral Component Of Membrane Vesicle	Basement Membrane Plasma Membrane Cell-cell Adherens Junction Focal Adhesion External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Hemidesmosome Filopodium Integrin Alpha6-beta4 Complex
	Molecular Function	Antigen Binding Integrin Binding	Integrin Binding Protein Binding Laminin Binding Metal Ion Binding
	Biological Process	Protein Complex Assembly	Cell-substrate Junction Assembly Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Hemidesmosome Assembly Cell-substrate Adhesion Cellular Response To Extracellular Stimulus Cell Adhesion Mediated By Integrin Cell Junction Assembly Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Filopodium Assembly Digestive Tract Development Brown Fat Cell Differentiation Leukocyte Migration Cellular Response To Organic Cyclic Compound Renal System Development Amelogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Alzheimer's disease biomarkers ( 23419831) Prostate cancer ( 19767753)
Protein-Protein Interactions		8 interactors: CD46 CD81 CD9 CLDN11 ITGA3 ITGA6 ITGB1 NOTCH2NL	21 interactors: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4
Entrez ID		7106	3655
HPRD ID		04033	00945
Ensembl ID		ENSG00000214063	ENSG00000091409
Uniprot IDs		A8MVV6 O14817	P23229
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell Adhesion Mediated By Integrin Reproduction Negative Regulation Of Rho Protein Signal Transduction Cell Adhesion Single Organism Reproductive Process Cell-matrix Adhesion Regulation Of Body Fluid Levels Reproductive Process Wound Healing Regulation Of Cell-substrate Adhesion Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell Junction Assembly Regulation Of Cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Cell-substrate Adhesion Mesodermal Cell Differentiation Leukocyte Migration Response To Wounding Response To Gonadotropin Sexual Reproduction Viral Entry Into Host Cell Regulation Of Establishment Of Protein Localization To Plasma Membrane Entry Into Host Cell Multicellular Organism Reproduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Signal Transduction Maternal Process Involved In Female Pregnancy Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Negative Regulation Of Signaling Mesoderm Formation Mesoderm Morphogenesis Locomotion Interaction With Host Cell-cell Junction Assembly Viral Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Single Fertilization Formation Of Primary Germ Layer Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component	Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Activation Cell-matrix Adhesion Cell Junction Assembly Cell Adhesion Platelet Activation Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cellular Component Assembly Secretion By Cell Regulation Of Body Fluid Levels Platelet Degranulation Response To Growth Factor Wound Healing Secretion Positive Regulation Of Endocytosis Positive Regulation Of Transport Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Movement Of Cell Or Subcellular Component Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Cell-cell Adhesion Mediated By Integrin Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Transport Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway
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