TSPAN4 and CD81

Number of citations of the paper that reports this interaction (PMID 9360996)
17

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		TSPAN4	CD81
Gene Name		tetraspanin 4	CD81 molecule
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integral Component Of Membrane Vesicle	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Integrin Binding	Protein Binding MHC Class II Protein Complex Binding
	Biological Process	Protein Complex Assembly	Activation Of MAPK Activity Phosphatidylinositol Biosynthetic Process Protein Localization Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Phosphatidylinositol Metabolic Process Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Regulation Of Cell Motility
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CD46 CD81 CD9 CLDN11 ITGA3 ITGA6 ITGB1 NOTCH2NL	20 interactors: ADRB2 CD19 CD9 CSNK2B DLG5 HNRNPD IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT MYOC PTGFRN RBBP6 RNF128 SHC1 TSPAN4 VKORC1 ZBTB16
Entrez ID		7106	975
HPRD ID		04033	08924
Ensembl ID		ENSG00000214063	ENSG00000110651
Uniprot IDs		A8MVV6 O14817	E9PJK1 P60033
PDB IDs			1G8Q 1IV5 2AVZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell Adhesion Mediated By Integrin Reproduction Negative Regulation Of Rho Protein Signal Transduction Cell Adhesion Single Organism Reproductive Process Cell-matrix Adhesion Regulation Of Body Fluid Levels Reproductive Process Wound Healing Regulation Of Cell-substrate Adhesion Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell Junction Assembly Regulation Of Cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Cell-substrate Adhesion Mesodermal Cell Differentiation Leukocyte Migration Response To Wounding Response To Gonadotropin Sexual Reproduction Viral Entry Into Host Cell Regulation Of Establishment Of Protein Localization To Plasma Membrane Entry Into Host Cell Multicellular Organism Reproduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Signal Transduction Maternal Process Involved In Female Pregnancy Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Negative Regulation Of Signaling Mesoderm Formation Mesoderm Morphogenesis Locomotion Interaction With Host Cell-cell Junction Assembly Viral Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Single Fertilization Formation Of Primary Germ Layer Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component	Organ Development ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation System Development Regulation Of Immune Response Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Developmental Process Positive Regulation Of Ossification B Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Response To Stress Negative Regulation Of Cell Proliferation Regulation Of Locomotion Cell Activation Regulation Of Cellular Component Movement B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Tissue Development Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Signal Transduction Innate Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Ossification Stem Cell Division Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Single Organismal Cell-cell Adhesion Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Cell Differentiation Bone Development Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Skeletal Muscle Hypertrophy Negative Regulation Of FasL Biosynthetic Process Zonula Adherens Assembly ERBB2-ERBB3 Signaling Pathway Mast Cell Proliferation Lymphocyte Differentiation
Tagcloud ?			000xg calreticulin centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vdac1 vesicle
Tagcloud (Difference) ?			000xg calreticulin centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin tsg101 ultracentrifugation vdac1 vesicle
Tagcloud (Intersection) ?