TSPAN4 and CD46

Number of citations of the paper that reports this interaction (PMID 10741407)
22

Data Source:
HPRD (in vivo)

		TSPAN4	CD46
Gene Name		tetraspanin 4	CD46 molecule, complement regulatory protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integral Component Of Membrane Vesicle	Inner Acrosomal Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Integrin Binding	Complement Binding Endopeptidase Activity Enzyme Inhibitor Activity Receptor Activity Protein Binding Cadherin Binding
	Biological Process	Protein Complex Assembly	Adaptive Immune Response T Cell Mediated Immunity Proteolysis Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Viral Process Regulation Of Complement Activation Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Negative Regulation Of Catalytic Activity Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Positive Regulation Of Transforming Growth Factor Beta Production
Pathways			Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Heart rate ( 23583979) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: CD46 CD81 CD9 CLDN11 ITGA3 ITGA6 ITGB1 NOTCH2NL	8 interactors: C3 DLG4 ITGB1 LLGL1 MSN SRC TSPAN4 YES1
Entrez ID		7106	4179
HPRD ID		04033	00406
Ensembl ID		ENSG00000214063	ENSG00000117335
Uniprot IDs		A8MVV6 O14817	P15529
PDB IDs			1CKL 1HR4 2O39 3INB 3L89 3O8E
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Cell Adhesion Mediated By Integrin Reproduction Negative Regulation Of Rho Protein Signal Transduction Cell Adhesion Single Organism Reproductive Process Cell-matrix Adhesion Regulation Of Body Fluid Levels Reproductive Process Wound Healing Regulation Of Cell-substrate Adhesion Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell Junction Assembly Regulation Of Cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Cell-substrate Adhesion Mesodermal Cell Differentiation Leukocyte Migration Response To Wounding Response To Gonadotropin Sexual Reproduction Viral Entry Into Host Cell Regulation Of Establishment Of Protein Localization To Plasma Membrane Entry Into Host Cell Multicellular Organism Reproduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Signal Transduction Maternal Process Involved In Female Pregnancy Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Negative Regulation Of Signaling Mesoderm Formation Mesoderm Morphogenesis Locomotion Interaction With Host Cell-cell Junction Assembly Viral Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Single Fertilization Formation Of Primary Germ Layer Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component	Regulation Of Endocytosis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Leukocyte Migration Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Maintenance Of Apical/basal Cell Polarity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Vesicle-mediated Transport Axon Guidance Cell Development Neuron Development Maintenance Of Cell Polarity Cell Morphogenesis Negative Regulation Of Anoikis Neuron Differentiation Cell Projection Organization Regulation Of Anoikis Locomotion Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Immune System Process Actin Cytoskeleton Organization Chemotaxis Cortical Actin Cytoskeleton Organization Actin Filament-based Process Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Permeability Generation Of Neurons Golgi To Plasma Membrane Transport Peptidyl-tyrosine Autophosphorylation Neurogenesis Cell Migration Regulation Of Immune Response Cell Motility Cellular Component Assembly Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Adhesion Protein Complex Assembly Dendrite Morphogenesis Immune System Process T Cell Costimulation Blood Coagulation Cytoskeleton Organization
Tagcloud ?			abc accelerating acinar apical cd55 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Difference) ?			abc accelerating acinar apical cd55 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
Tagcloud (Intersection) ?