SERPING1 and SELP

Number of citations of the paper that reports this interaction (PubMedID 14568956)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SERPING1	SELP
Description		serpin family G member 1	selectin P
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Lipopolysaccharide Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Metal Ion Binding Calcium-dependent Protein Binding Oligosaccharide Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis Blood Circulation Fibrinolysis	Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Response To Cytokine Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Platelet degranulation Cell surface interactions at the vascular wall
Drugs		PPL-100 Copper	Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Monocyte count ( 32888494) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Interacting Genes		17 interacting genes: BAG6 C1R C1S CFTR ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN
Entrez ID		710	6403
HPRD ID		06033	01433
Ensembl ID		ENSG00000149131	ENSG00000174175
Uniprot IDs		E9KL26 P05155	B2R785 P16109 Q5R341 Q6NUL9
PDB IDs		2OAY 5DU3 5DUQ 7AKV 8W18	1FSB 1G1Q 1G1R 1G1S 1HES
Enriched GO Terms of Interacting Partners?		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Response To External Biotic Stimulus Zymogen Activation Activation Of Membrane Attack Complex Immune System Process Killing Of Cells Of Another Organism Opsonization Symbiont Cell Surface Peptidase Activity Extracellular Space Protein Processing Response To Other Organism Response To Stress Cell Killing Cell Surface Positive Regulation Of Leukocyte Tethering Or Rolling Defense Response Positive Regulation Of Immune System Process Negative Regulation Of Fibrinolysis Complement Activation Regulation Of Leukocyte Tethering Or Rolling Protein Maturation Proteolysis Regulation Of Fibrinolysis Fibrinolysis Immune Effector Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Immune Response Activation Of Immune Response Positive Regulation Of Blood Coagulation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Coagulation Defense Response To Symbiont Humoral Immune Response Defense Response To Other Organism Complement Activation, Classical Pathway Blood Microparticle Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Lipopolysaccharide Binding Trans-synaptic Signaling By BDNF Regulation Of Immune System Process Extracellular Region Biological Process Involved In Interaction With Symbiont Hydrolase Activity Complement Component C1 Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Cell Migration Negative Regulation Of Blood Coagulation	Localization Within Membrane Uropod Fibrinolysis Cell Migration Cell Adhesion Cellular Localization Receptor-mediated Endocytosis Establishment Of Localization In Cell Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Cell Motility Intracellular Protein Localization IgE Receptor Activity Vesicle-mediated Transport Leukocyte Migration Cell Activation Cell Surface Regulation Of Platelet Activation Leukocyte Cell-cell Adhesion Plasma Membrane Raft Immunological Synapse Intracellular Protein Transport Establishment Of Natural Killer Cell Polarity Negative Regulation Of Transforming Growth Factor Beta3 Production B Cell Receptor Transport Into Membrane Raft Chemokine Receptor Transport Out Of Membrane Raft Membrane Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Receptor Internalization Protein Localization To Membrane Regulation Of Hemostasis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Type I Hypersensitivity External Side Of Plasma Membrane Fc-epsilon Receptor I Complex Lewis X Epitope Biosynthetic Process Leukocyte Adhesive Activation Terminal Web Assembly Early Endosome Endocytic Recycling Glomerular Parietal Epithelial Cell Differentiation Blood Coagulation Regulation Of Immune System Process Interphotoreceptor Matrix Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity
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