SELP and SNX27

Number of citations of the paper that reports this interaction (PMID 23382219)
5

Data Source:
BioGRID (pull down)

		SELP	SNX27
Gene Name		selectin P (granule membrane protein 140kDa, antigen CD62)	sorting nexin family member 27
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Immunological Synapse Nucleoplasm Cytoplasm Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex
	Molecular Function	Lipopolysaccharide Binding Glycoprotein Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Blood Coagulation Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Response To Lipopolysaccharide Regulation Of Integrin Activation Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall
Drugs		Heparin O-Sialic Acid Dalteparin Nadroparin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Hippocampal atrophy ( 22745009) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Protein-Protein Interactions		10 interactors: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	6 interactors: AKT2 APP DGKZ HLCS PNPLA3 SELP
Entrez ID		6403	81609
HPRD ID		01433	11591
Ensembl ID		ENSG00000174175	ENSG00000143376
Uniprot IDs		P16109 Q5R341 Q6NUL9	Q96L92
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES 1KJD	4HAS
Enriched GO Terms of Interacting Partners?		Cell Activation Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Cell Adhesion Fibrinolysis Endosomal Transport Cellular Protein Localization Cellular Localization Negative Regulation Of Blood Coagulation Leukocyte Cell-cell Adhesion Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Intracellular Protein Transport Chemokine Receptor Transport Out Of Membrane Raft B Cell Receptor Transport Into Membrane Raft Negative Regulation Of Transforming Growth Factor Beta3 Production Establishment Of Natural Killer Cell Polarity Protein Localization Blood Coagulation Hemostasis Regulation Of Blood Coagulation Establishment Of Localization In Cell Negative Regulation Of Complement Activation, Lectin Pathway Leukocyte Adhesive Activation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Leukocyte Activation Immune System Process Single Organismal Cell-cell Adhesion Locomotion Regulation Of T Cell Homeostatic Proliferation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Protein Transport Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Integrin Activation Positive Regulation Of B Cell Apoptotic Process Endocytosis Protein Activation Cascade Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Negative Regulation Of Transforming Growth Factor Beta Production Intracellular Transport Response To Wounding Platelet Activation Pigment Granule Maturation L-fucose Catabolic Process	Platelet Activation Blood Coagulation Hemostasis Platelet Degranulation Regulation Of Cell Cycle Process Protein Biotinylation Histone Biotinylation Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Synaptic Growth At Neuromuscular Junction Response To Biotin Selenium Compound Metabolic Process Collateral Sprouting In Absence Of Injury Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Acylglycerol Acyl-chain Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Glucose Import In Response To Insulin Stimulus Locomotory Behavior Axon Choice Point Recognition Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Platelet Activation Regulation Of Translation Regulation Of Signal Transduction Neuron Remodeling Phosphate-containing Compound Metabolic Process Locomotion Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Integrin Activation Lipid Metabolic Process Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Vesicle Fusion Biotin Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Leukocyte Tethering Or Rolling Regulation Of Signaling Regulation Of Mitotic Cell Cycle
Tagcloud ?			40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector
Tagcloud (Difference) ?			40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector
Tagcloud (Intersection) ?