SELP and FUT4

Number of citations of the paper that reports this interaction (PubMedID 7508745)
0

Data Source:
HPRD (in vitro)

		SELP	FUT4
Description		selectin P	fucosyltransferase 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cell Surface Membrane Golgi Cisterna Membrane Cell Periphery
	Molecular Function	Lipopolysaccharide Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Metal Ion Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Fucosyltransferase Activity Transferase Activity Glycosyltransferase Activity 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Response To Cytokine Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling	Carbohydrate Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Protein O-linked Glycosylation Sphingolipid Metabolic Process Glycosphingolipid Biosynthetic Process Inflammatory Response Oligosaccharide Metabolic Process Oligosaccharide Biosynthetic Process Fucosylation L-fucose Catabolic Process Lymphocyte Migration Into Lymph Node Lewis X Epitope Biosynthetic Process Positive Regulation Of Neutrophil Migration Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Cell surface interactions at the vascular wall	Lewis blood group biosynthesis
Drugs		Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Monocyte count ( 32888494) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)	Metabolite levels ( 23823483) Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498) Small cell lung carcinoma ( 28604730)
Interacting Genes		10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	3 interacting genes: CR1 ITGB2 SELP
Entrez ID		6403	2526
HPRD ID		01433	00083
Ensembl ID		ENSG00000174175	ENSG00000196371
Uniprot IDs		B2R785 P16109 Q5R341 Q6NUL9	P22083
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES
Enriched GO Terms of Interacting Partners?		Localization Within Membrane Uropod Fibrinolysis Cell Migration Cell Adhesion Cellular Localization Receptor-mediated Endocytosis Establishment Of Localization In Cell Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Cell Motility Intracellular Protein Localization IgE Receptor Activity Vesicle-mediated Transport Leukocyte Migration Cell Activation Cell Surface Regulation Of Platelet Activation Leukocyte Cell-cell Adhesion Plasma Membrane Raft Immunological Synapse Intracellular Protein Transport Establishment Of Natural Killer Cell Polarity Negative Regulation Of Transforming Growth Factor Beta3 Production B Cell Receptor Transport Into Membrane Raft Chemokine Receptor Transport Out Of Membrane Raft Membrane Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Receptor Internalization Protein Localization To Membrane Regulation Of Hemostasis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Type I Hypersensitivity External Side Of Plasma Membrane Fc-epsilon Receptor I Complex Lewis X Epitope Biosynthetic Process Leukocyte Adhesive Activation Terminal Web Assembly Early Endosome Endocytic Recycling Glomerular Parietal Epithelial Cell Differentiation Blood Coagulation Regulation Of Immune System Process Interphotoreceptor Matrix Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity	Complement Component C3b Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane Raft Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Ficolin-1-rich Granule Membrane Leukocyte Cell-cell Adhesion Regulation Of Cell Adhesion Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Immune System Process Integrin Binding Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Plasma Cell Differentiation Complement Component C4b Binding Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Integrin AlphaL-beta2 Complex Negative Regulation Of Activation Of Membrane Attack Complex Defense Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Complement Activation, Alternative Pathway Immune Complex Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules ICAM-3 Receptor Activity Leukocyte Migration Positive Regulation Of Neutrophil Degranulation Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Immune Effector Process Regulation Of Immune System Process Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Complement Activation ATP Export Platelet Dense Granule Membrane Glycosphingolipid Binding Negative Regulation Of B Cell Differentiation Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Neutrophil Degranulation External Side Of Plasma Membrane Fucose Binding
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