SELP and FUT4

Number of citations of the paper that reports this interaction (PMID 7508745)
5

Data Source:
HPRD (in vitro)

		SELP	FUT4
Gene Name		selectin P (granule membrane protein 140kDa, antigen CD62)	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Golgi Apparatus Cell Surface Membrane Integral Component Of Membrane Golgi Cisterna Membrane Cell Periphery
	Molecular Function	Lipopolysaccharide Binding Glycoprotein Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Fucosyltransferase Activity Alpha-(1->3)-fucosyltransferase Activity
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Blood Coagulation Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Response To Lipopolysaccharide Regulation Of Integrin Activation Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling	Carbohydrate Metabolic Process Protein Glycosylation Fucosylation L-fucose Catabolic Process
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall
Drugs		Heparin O-Sialic Acid Dalteparin Nadroparin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Hippocampal atrophy ( 22745009) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)	Response to angiotensin II receptor blocker therapy ( 22566498) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498)
Protein-Protein Interactions		10 interactors: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	3 interactors: CR1 ITGB2 SELP
Entrez ID		6403	2526
HPRD ID		01433	00083
Ensembl ID		ENSG00000174175	ENSG00000196371
Uniprot IDs		P16109 Q5R341 Q6NUL9	P22083
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES 1KJD
Enriched GO Terms of Interacting Partners?		Cell Activation Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Cell Adhesion Fibrinolysis Endosomal Transport Cellular Protein Localization Cellular Localization Negative Regulation Of Blood Coagulation Leukocyte Cell-cell Adhesion Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Intracellular Protein Transport Chemokine Receptor Transport Out Of Membrane Raft B Cell Receptor Transport Into Membrane Raft Negative Regulation Of Transforming Growth Factor Beta3 Production Establishment Of Natural Killer Cell Polarity Protein Localization Blood Coagulation Hemostasis Regulation Of Blood Coagulation Establishment Of Localization In Cell Negative Regulation Of Complement Activation, Lectin Pathway Leukocyte Adhesive Activation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Leukocyte Activation Immune System Process Single Organismal Cell-cell Adhesion Locomotion Regulation Of T Cell Homeostatic Proliferation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Protein Transport Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Integrin Activation Positive Regulation Of B Cell Apoptotic Process Endocytosis Protein Activation Cascade Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Negative Regulation Of Transforming Growth Factor Beta Production Intracellular Transport Response To Wounding Platelet Activation Pigment Granule Maturation L-fucose Catabolic Process	Cellular Extravasation Positive Regulation Of Immune System Process Positive Regulation Of Serine-type Endopeptidase Activity Regulation Of Immune System Process Defense Response Selenium Compound Metabolic Process Negative Regulation Of Complement Activation, Alternative Pathway Leukocyte Migration Regulation Of Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Leukocyte Cell-cell Adhesion Complement Receptor Mediated Signaling Pathway Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Platelet Activation Inflammatory Response Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Regulation Of Integrin Activation Leukocyte Migration Involved In Inflammatory Response Single Organismal Cell-cell Adhesion Leukocyte Tethering Or Rolling Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Complement Activation Positive Regulation Of Immune Response Cell Activation Response To Wounding Heterotypic Cell-cell Adhesion Activated T Cell Proliferation Response To Stress Innate Immune Response Cell Migration Regulation Of Platelet Activation Regulation Of Immune Response Positive Regulation Of Blood Coagulation Regulation Of Complement Activation Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Nitric Oxide Biosynthetic Process Defense Response To Gram-negative Bacterium Negative Regulation Of Adaptive Immune Response Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Innate Immune Response Positive Regulation Of Coagulation Neutrophil Chemotaxis
Tagcloud ?			a431 abolished akt asssociated carbohydrate catalyzes cdk correlates crosstalk difucosylated erk1 fucosyltransferase herein lewis ley ly294002 mapk mapks oligosaccharide p27 p38 pd98059 phosphoinositide pi3k prb promotes sb203580 upstream wortmannin
Tagcloud (Difference) ?			a431 abolished akt asssociated carbohydrate catalyzes cdk correlates crosstalk difucosylated erk1 fucosyltransferase herein lewis ley ly294002 mapk mapks oligosaccharide p27 p38 pd98059 phosphoinositide pi3k prb promotes sb203580 upstream wortmannin
Tagcloud (Intersection) ?