SERPING1 and MASP2

Number of citations of the paper that reports this interaction (PMID 10946292)
29

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		SERPING1	MASP2
Gene Name		serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	mannan-binding lectin serine peptidase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Complement Component C4b Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Platelet Activation Fibrinolysis Innate Immune Response	Complement Activation, Lectin Pathway Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP	3 interactors: FCN2 MBL2 SERPING1
Entrez ID		710	10747
HPRD ID		06033	05484
Ensembl ID		ENSG00000149131	ENSG00000009724
Uniprot IDs		B4E1F0 E9KL26 P05155	O00187
PDB IDs		1M6Q 2OAY	1Q3X 1SZB 1ZJK 3TVJ 4FXG
Enriched GO Terms of Interacting Partners?		Immune System Process Response To Stress Defense Response Proteolysis Protein Activation Cascade Regulation Of Immune System Process Leukocyte Migration Cell Migration Positive Regulation Of Immune System Process Cell Motility Regulation Of Blood Coagulation Fibrinolysis Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Complement Activation Negative Regulation Of Protein Processing Response To Stimulus Positive Regulation Of Coagulation Locomotion Regulation Of Protein Processing Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Movement Of Cell Or Subcellular Component Complement Activation, Lectin Pathway Humoral Immune Response Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels Leukocyte Mediated Immunity Wound Healing Negative Regulation Of Fibrinolysis Positive Regulation Of Immune Response Response To Wounding Leukocyte Tethering Or Rolling Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Immune Response Complement Activation, Classical Pathway Innate Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Lipid Inflammatory Response Cellular Extravasation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Platelet Activation	Complement Activation Complement Activation, Lectin Pathway Protein Activation Cascade Opsonization Humoral Immune Response Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response Regulation Of Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Defense Response Defense Response To Bacterium Vesicle-mediated Transport Negative Regulation Of Complement Activation, Lectin Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Phagocytosis Leukocyte Mediated Immunity Adaptive Immune Response Immune System Process Recognition Of Apoptotic Cell Killing By Host Of Symbiont Cells Response To Bacterium Negative Regulation Of Complement Activation Blood Coagulation, Intrinsic Pathway Phagocytosis, Recognition Endocytosis Response To Other Organism Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To Stress Negative Regulation Of Growth Of Symbiont In Host Fibrinolysis Regulation Of Complement Activation Apoptotic Cell Clearance Interaction With Symbiont Defense Response To Gram-negative Bacterium Negative Regulation Of Innate Immune Response Acute-phase Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Phagocytosis Negative Regulation Of Wound Healing
Tagcloud ?		2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	2d apoa1 apoa4 biochemistry bioinformatic cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Difference) ?		2j aif1 amd bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	2d apoa1 apoa4 biochemistry cfhr1 clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Intersection) ?		bioinformatic