SELP and AP1M1

Number of citations of the paper that reports this interaction (PMID 11247301)
10

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		SELP	AP1M1
Gene Name		selectin P (granule membrane protein 140kDa, antigen CD62)	adaptor-related protein complex 1, mu 1 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Golgi Membrane Lysosomal Membrane Cytosol Membrane Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Extracellular Vesicular Exosome
	Molecular Function	Lipopolysaccharide Binding Glycoprotein Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Protein Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Blood Coagulation Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Response To Lipopolysaccharide Regulation Of Integrin Activation Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs		Heparin O-Sialic Acid Dalteparin Nadroparin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Hippocampal atrophy ( 22745009) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Protein-Protein Interactions		10 interactors: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	43 interactors: AP1B1 AP1M2 AP2B1 BRCA1 CEP57L1 CORO7 CTLA4 DCX DVL2 DZIP3 EHD2 ETV6 FAM9B FXR2 GAK GRIN2A GRIN2B HNRNPC HOOK2 IKZF1 KIF13A KRT40 KRTAP10-3 KRTAP10-7 LAMP1 LDOC1 LZTS2 MTF1 PHC2 PIGR PNMA5 RUNDC3A SDCCAG3 SELP SSX2IP TGOLN2 TIFA TNIP1 VAMP4 ZBTB14 ZBTB43 ZBTB44 ZBTB8A
Entrez ID		6403	8907
HPRD ID		01433	04639
Ensembl ID		ENSG00000174175	ENSG00000072958
Uniprot IDs		P16109 Q5R341 Q6NUL9	B3KNH5 E7ENJ6 Q59EK3 Q9BXS5
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES 1KJD
Enriched GO Terms of Interacting Partners?		Cell Activation Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Cell Adhesion Fibrinolysis Endosomal Transport Cellular Protein Localization Cellular Localization Negative Regulation Of Blood Coagulation Leukocyte Cell-cell Adhesion Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Intracellular Protein Transport Chemokine Receptor Transport Out Of Membrane Raft B Cell Receptor Transport Into Membrane Raft Negative Regulation Of Transforming Growth Factor Beta3 Production Establishment Of Natural Killer Cell Polarity Protein Localization Blood Coagulation Hemostasis Regulation Of Blood Coagulation Establishment Of Localization In Cell Negative Regulation Of Complement Activation, Lectin Pathway Leukocyte Adhesive Activation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Leukocyte Activation Immune System Process Single Organismal Cell-cell Adhesion Locomotion Regulation Of T Cell Homeostatic Proliferation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Protein Transport Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Integrin Activation Positive Regulation Of B Cell Apoptotic Process Endocytosis Protein Activation Cascade Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Negative Regulation Of Transforming Growth Factor Beta Production Intracellular Transport Response To Wounding Platelet Activation Pigment Granule Maturation L-fucose Catabolic Process	Vesicle-mediated Transport Cellular Localization Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Defense Response To Virus By Virus Intracellular Transport Endosomal Transport Protein Localization Lysosomal Transport Golgi Vesicle Transport Regulation Of Immune System Process Cellular Protein Localization Vacuolar Transport Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Microtubule Cytoskeleton Organization Endomembrane System Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Transport Regulation Of Cellular Process Startle Response Microtubule-based Process Endosome To Lysosome Transport Positive Regulation Of Cell Activation Cytoskeleton Organization Clathrin-mediated Endocytosis Establishment Of Protein Localization Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Histone H4-K20 Methylation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Histone H4-K16 Acetylation Membrane Organization Cellular Protein Complex Assembly Organelle Organization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Intrahepatic Bile Duct Development Positive Regulation Of Natural Killer Cell Degranulation Selenium Compound Metabolic Process Cytoplasmic Transport Glutamate Receptor Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Golgi To Lysosome Transport Neuron-neuron Synaptic Transmission
Tagcloud ?			19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic
Tagcloud (Difference) ?			19p13 adaptor ap1m2 ap2m1 chromosome clathrin cloned closely distantly diverged duplication except exclusively fact genomic homolog identical insertion intron introns mapped mu1a mu1b mu2 positions proximal separation similarity syntenic
Tagcloud (Intersection) ?