SELP

Description		selectin P
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane
	Molecular Function	Lipopolysaccharide Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Metal Ion Binding Calcium-dependent Protein Binding Oligosaccharide Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Response To Cytokine Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Cell surface interactions at the vascular wall
Drugs		Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Monocyte count ( 32888494) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Novel Interacting Genes		1 novel interacting genes: FCER1G
Interacting Genes		10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN
Entrez ID		6403
HPRD ID		01433
Ensembl ID		ENSG00000174175
Uniprot IDs		B2R785 P16109 Q5R341 Q6NUL9
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES
Enriched GO Terms of Interacting Partners?		Localization Within Membrane Uropod Fibrinolysis Cell Migration Cell Adhesion Cellular Localization Receptor-mediated Endocytosis Establishment Of Localization In Cell Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Cell Motility Intracellular Protein Localization IgE Receptor Activity Vesicle-mediated Transport Leukocyte Migration Cell Activation Cell Surface Regulation Of Platelet Activation Leukocyte Cell-cell Adhesion Plasma Membrane Raft Immunological Synapse Intracellular Protein Transport Establishment Of Natural Killer Cell Polarity Negative Regulation Of Transforming Growth Factor Beta3 Production B Cell Receptor Transport Into Membrane Raft Chemokine Receptor Transport Out Of Membrane Raft Membrane Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Receptor Internalization Protein Localization To Membrane Regulation Of Hemostasis Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Type I Hypersensitivity External Side Of Plasma Membrane Fc-epsilon Receptor I Complex Lewis X Epitope Biosynthetic Process Leukocyte Adhesive Activation Terminal Web Assembly Early Endosome Endocytic Recycling Glomerular Parietal Epithelial Cell Differentiation Blood Coagulation Regulation Of Immune System Process Interphotoreceptor Matrix Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Type III Hypersensitivity
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