SELP and EZR

Number of citations of the paper that reports this interaction (PMID 10733515)
27

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		SELP	EZR
Gene Name		selectin P (granule membrane protein 140kDa, antigen CD62)	ezrin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus
	Molecular Function	Lipopolysaccharide Binding Glycoprotein Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Blood Coagulation Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Response To Lipopolysaccharide Regulation Of Integrin Activation Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall	Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1
Drugs		Heparin O-Sialic Acid Dalteparin Nadroparin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Hippocampal atrophy ( 22745009) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Protein-Protein Interactions		10 interactors: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX
Entrez ID		6403	7430
HPRD ID		01433	00475
Ensembl ID		ENSG00000174175	ENSG00000092820
Uniprot IDs		P16109 Q5R341 Q6NUL9	P15311
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES 1KJD	1NI2
Enriched GO Terms of Interacting Partners?		Cell Activation Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Cell Adhesion Fibrinolysis Endosomal Transport Cellular Protein Localization Cellular Localization Negative Regulation Of Blood Coagulation Leukocyte Cell-cell Adhesion Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Intracellular Protein Transport Chemokine Receptor Transport Out Of Membrane Raft B Cell Receptor Transport Into Membrane Raft Negative Regulation Of Transforming Growth Factor Beta3 Production Establishment Of Natural Killer Cell Polarity Protein Localization Blood Coagulation Hemostasis Regulation Of Blood Coagulation Establishment Of Localization In Cell Negative Regulation Of Complement Activation, Lectin Pathway Leukocyte Adhesive Activation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Leukocyte Activation Immune System Process Single Organismal Cell-cell Adhesion Locomotion Regulation Of T Cell Homeostatic Proliferation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Protein Transport Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Integrin Activation Positive Regulation Of B Cell Apoptotic Process Endocytosis Protein Activation Cascade Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Negative Regulation Of Transforming Growth Factor Beta Production Intracellular Transport Response To Wounding Platelet Activation Pigment Granule Maturation L-fucose Catabolic Process	Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels
Tagcloud ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?			actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?