SERPING1 and SELE

Number of citations of the paper that reports this interaction (PMID 14568956)
15

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SERPING1	SELE
Gene Name		serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	selectin E
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Caveola Coated Pit Integral Component Of Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Oligosaccharide Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Platelet Activation Fibrinolysis Innate Immune Response	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Leukocyte Migration Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Blood Coagulation Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1
Pathways		Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	Cell surface interactions at the vascular wall
Drugs			O-Sialic Acid
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP	13 interactors: ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 VCL
Entrez ID		710	6401
HPRD ID		06033	00566
Ensembl ID		ENSG00000149131	ENSG00000007908
Uniprot IDs		B4E1F0 E9KL26 P05155	P16581
PDB IDs		1M6Q 2OAY	1ESL 1G1T 1KJA
Enriched GO Terms of Interacting Partners?		Immune System Process Response To Stress Defense Response Proteolysis Protein Activation Cascade Regulation Of Immune System Process Leukocyte Migration Cell Migration Positive Regulation Of Immune System Process Cell Motility Regulation Of Blood Coagulation Fibrinolysis Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Complement Activation Negative Regulation Of Protein Processing Response To Stimulus Positive Regulation Of Coagulation Locomotion Regulation Of Protein Processing Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Movement Of Cell Or Subcellular Component Complement Activation, Lectin Pathway Humoral Immune Response Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels Leukocyte Mediated Immunity Wound Healing Negative Regulation Of Fibrinolysis Positive Regulation Of Immune Response Response To Wounding Leukocyte Tethering Or Rolling Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Immune Response Complement Activation, Classical Pathway Innate Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Lipid Inflammatory Response Cellular Extravasation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Platelet Activation	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Movement Of Cell Or Subcellular Component Leukocyte Migration Cell Adhesion Platelet Activation Platelet Degranulation Cell Migration Cell Motility Cell Projection Organization Cell Activation Cell Morphogenesis Involved In Differentiation Response To Stimulus Locomotion Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Adherens Junction Assembly Positive Regulation Of Intracellular Signal Transduction Cell Junction Assembly Vesicle-mediated Transport Cell-substrate Adhesion Immune System Process Regulation Of Protein Metabolic Process Signal Complex Assembly Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Cell Morphogenesis Response To Growth Factor Adherens Junction Organization Cell Projection Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Exocytosis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Defense Response Integrin-mediated Signaling Pathway Innate Immune Response Protein Localization To Cell Surface Cell Projection Morphogenesis Regulation Of Signaling Cell Part Morphogenesis Positive Regulation Of Phosphorylation Regulation Of Immune Response Positive Regulation Of MAPK Cascade
Tagcloud ?		2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated
Tagcloud (Difference) ?		2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	2000bp 500bp annotated cor cst11 cyp2b13 cyp2b9 cyp2d9 cyp3a41 cyp3a44 cyp4a10 cyp7b1 ddc defb43 esr2 fmo3 hsd3b5 hypo masculinization masculinize methylatable nimblegen permanently slco1a1 sult2a2 tss ugt2b1 ugt2b38 unmethylated
Tagcloud (Intersection) ?