SERPING1 and ELANE

Number of citations of the paper that reports this interaction (PMID 6980881)
26

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		SERPING1	ELANE
Gene Name		serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	elastase, neutrophil expressed
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Platelet Activation Fibrinolysis Innate Immune Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus
Pathways		Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs			Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP	30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS
Entrez ID		710	1991
HPRD ID		06033	00554
Ensembl ID		ENSG00000149131	ENSG00000197561
Uniprot IDs		B4E1F0 E9KL26 P05155	P08246
PDB IDs		1M6Q 2OAY	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77
Enriched GO Terms of Interacting Partners?		Immune System Process Response To Stress Defense Response Proteolysis Protein Activation Cascade Regulation Of Immune System Process Leukocyte Migration Cell Migration Positive Regulation Of Immune System Process Cell Motility Regulation Of Blood Coagulation Fibrinolysis Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Complement Activation Negative Regulation Of Protein Processing Response To Stimulus Positive Regulation Of Coagulation Locomotion Regulation Of Protein Processing Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Movement Of Cell Or Subcellular Component Complement Activation, Lectin Pathway Humoral Immune Response Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels Leukocyte Mediated Immunity Wound Healing Negative Regulation Of Fibrinolysis Positive Regulation Of Immune Response Response To Wounding Leukocyte Tethering Or Rolling Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Immune Response Complement Activation, Classical Pathway Innate Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Lipid Inflammatory Response Cellular Extravasation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Platelet Activation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation
Tagcloud ?		2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Difference) ?		2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Intersection) ?