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SERPING1
Description
serpin family G member 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Peptidase Inhibitor Activity
Biological Process
Negative Regulation Of Complement Activation, Lectin Pathway
Blood Coagulation
Hemostasis
Blood Circulation
Fibrinolysis
Pathways
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Defective SERPING1 causes hereditary angioedema
Regulation of Complement cascade
Drugs
PPL-100
Copper
Diseases
Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
Hereditary angioedema
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Mean platelet volume (
32888494
)
Neuroticism (
29255261
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
17 interacting genes:
BAG6
C1R
C1S
CFTR
ELANE
ENO1
F2
HSP90AA1
MASP1
MASP2
NR4A1
PLAT
PLG
SELE
SELP
SLC30A2
SRPK2
Entrez ID
710
HPRD ID
06033
Ensembl ID
ENSG00000149131
Uniprot IDs
E9KL26
P05155
PDB IDs
2OAY
5DU3
5DUQ
7AKV
8W18
Enriched GO Terms of Interacting Partners
?
Serine-type Peptidase Activity
Serine-type Endopeptidase Activity
Response To External Biotic Stimulus
Zymogen Activation
Activation Of Membrane Attack Complex
Immune System Process
Killing Of Cells Of Another Organism
Opsonization
Symbiont Cell Surface
Peptidase Activity
Extracellular Space
Protein Processing
Response To Other Organism
Response To Stress
Cell Killing
Cell Surface
Positive Regulation Of Leukocyte Tethering Or Rolling
Defense Response
Positive Regulation Of Immune System Process
Negative Regulation Of Fibrinolysis
Complement Activation
Regulation Of Leukocyte Tethering Or Rolling
Protein Maturation
Proteolysis
Regulation Of Fibrinolysis
Fibrinolysis
Immune Effector Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Immune Response
Activation Of Immune Response
Positive Regulation Of Blood Coagulation
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Positive Regulation Of Coagulation
Defense Response To Symbiont
Humoral Immune Response
Defense Response To Other Organism
Complement Activation, Classical Pathway
Blood Microparticle
Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of Cellular Extravasation
Lipopolysaccharide Binding
Trans-synaptic Signaling By BDNF
Regulation Of Immune System Process
Extracellular Region
Biological Process Involved In Interaction With Symbiont
Hydrolase Activity
Complement Component C1 Complex
Neutrophil-mediated Killing Of Gram-negative Bacterium
Cell Migration
Negative Regulation Of Blood Coagulation
Tagcloud
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