SERPING1

Name	serpin family G member 1
Structure
Interactors	17 interactors: BAG6 C1R C1S CFTR ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis Blood Circulation Fibrinolysis
Pathways	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade
Drugs	PPL-100 Copper
Diseases	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS	Autism spectrum disorder or schizophrenia ( 28540026 ) Mean platelet volume ( 32888494 ) Neuroticism ( 29255261 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Schizophrenia ( 25056061 29483656 )
Entrez ID	710
HPRD ID	06033
Ensembl ID	ENSG00000149131
Uniprot IDs	E9KL26 P05155
PDB IDs	2OAY 5DU3 5DUQ 7AKV 8W18
GO Terms Enriched among Interactors ?	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Response To External Biotic Stimulus Zymogen Activation Activation Of Membrane Attack Complex Immune System Process Killing Of Cells Of Another Organism Opsonization Symbiont Cell Surface Peptidase Activity Extracellular Space Protein Processing Response To Other Organism Response To Stress Cell Killing Cell Surface Positive Regulation Of Leukocyte Tethering Or Rolling Defense Response Positive Regulation Of Immune System Process Negative Regulation Of Fibrinolysis Complement Activation Regulation Of Leukocyte Tethering Or Rolling Protein Maturation Proteolysis Regulation Of Fibrinolysis Fibrinolysis Immune Effector Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Immune Response Activation Of Immune Response Positive Regulation Of Blood Coagulation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Coagulation Defense Response To Symbiont Humoral Immune Response Defense Response To Other Organism Complement Activation, Classical Pathway Blood Microparticle Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Lipopolysaccharide Binding Trans-synaptic Signaling By BDNF Regulation Of Immune System Process Extracellular Region Biological Process Involved In Interaction With Symbiont Hydrolase Activity Complement Component C1 Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Cell Migration Negative Regulation Of Blood Coagulation