SERPING1 and C1R

Number of citations: 28 (PubMedID 6282262)
Data Source: BioGRID (biochemical), HPRD (in vitro)

		SERPING1	C1R
Name		serpin family G member 1	complement C1r
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Molecular Sequestering Activity
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis Blood Circulation Fibrinolysis	Activation Of Membrane Attack Complex Immune System Process Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		PPL-100 Copper	Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Mean platelet volume ( 32888494 ) Neuroticism ( 29255261 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Schizophrenia ( 25056061 29483656 )	No GWAS studies recorded
Interacting Genes		17 interacting genes: BAG6 C1R C1S CFTR ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		710	715
HPRD ID		06033	01954
Ensembl ID		ENSG00000149131	ENSG00000159403
Uniprot IDs		E9KL26 P05155	A0A3B3ISR2 B4DPQ0 P00736
PDB IDs		2OAY 5DU3 5DUQ 7AKV 8W18	1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39 9EKD 9EKE
GO Terms Enriched among Interactors		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Response To External Biotic Stimulus Zymogen Activation Activation Of Membrane Attack Complex Immune System Process Killing Of Cells Of Another Organism Opsonization Symbiont Cell Surface Peptidase Activity Extracellular Space Protein Processing Response To Other Organism Response To Stress Cell Killing Cell Surface Positive Regulation Of Leukocyte Tethering Or Rolling Defense Response Positive Regulation Of Immune System Process Negative Regulation Of Fibrinolysis Complement Activation Regulation Of Leukocyte Tethering Or Rolling Protein Maturation Proteolysis Regulation Of Fibrinolysis Fibrinolysis Immune Effector Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Immune Response Activation Of Immune Response Positive Regulation Of Blood Coagulation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Coagulation Defense Response To Symbiont Humoral Immune Response Defense Response To Other Organism Complement Activation, Classical Pathway Blood Microparticle Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Lipopolysaccharide Binding Trans-synaptic Signaling By BDNF Regulation Of Immune System Process Extracellular Region Biological Process Involved In Interaction With Symbiont Hydrolase Activity Complement Component C1 Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Cell Migration Negative Regulation Of Blood Coagulation	Complement Component C1 Complex Symbiont Cell Surface Complement Component C1q Complex Complement Activation, Classical Pathway Regulation Of Immune Response IgM Binding Complement Activation Positive Regulation Of Immune Response Synapse Pruning Regulation Of Immune System Process IgG Binding Blood Microparticle Activation Of Immune Response Tricarboxylic Acid Metabolic Process Positive Regulation Of Immune System Process Humoral Immune Response Gluconeogenesis Phosphatidylserine Binding Protein Maturation Hexose Biosynthetic Process Pyruvate Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Protein Serine Kinase Activity (using GTP As Donor) Collagen Trimer Immune Effector Process Negative Regulation Of Complement Activation, Lectin Pathway Extracellular Matrix Response To Stress Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process Response To Other Organism Protein Localization To Chromosome Carbohydrate Biosynthetic Process Vertebrate Eye-specific Patterning