SERPING1 and C1S

Number of citations of the paper that reports this interaction (PMID 3756141)
46

Data Source:
HPRD (in vitro, in vivo)

		SERPING1	C1S
Gene Name		serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	complement component 1, s subcomponent
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Aging Blood Coagulation Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Platelet Activation Fibrinolysis Innate Immune Response	Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs			Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP	4 interactors: C1QA C1R SERPING1 VKORC1
Entrez ID		710	716
HPRD ID		06033	00397
Ensembl ID		ENSG00000149131	ENSG00000182326
Uniprot IDs		B4E1F0 E9KL26 P05155	F8WCZ6 P09871
PDB IDs		1M6Q 2OAY	1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS
Enriched GO Terms of Interacting Partners?		Immune System Process Response To Stress Defense Response Proteolysis Protein Activation Cascade Regulation Of Immune System Process Leukocyte Migration Cell Migration Positive Regulation Of Immune System Process Cell Motility Regulation Of Blood Coagulation Fibrinolysis Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Complement Activation Negative Regulation Of Protein Processing Response To Stimulus Positive Regulation Of Coagulation Locomotion Regulation Of Protein Processing Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Movement Of Cell Or Subcellular Component Complement Activation, Lectin Pathway Humoral Immune Response Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels Leukocyte Mediated Immunity Wound Healing Negative Regulation Of Fibrinolysis Positive Regulation Of Immune Response Response To Wounding Leukocyte Tethering Or Rolling Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Immune Response Complement Activation, Classical Pathway Innate Immune Response Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Lipid Inflammatory Response Cellular Extravasation Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Regulation Of Platelet Activation	Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Complement Activation, Lectin Pathway Response To Stress Immune Response Regulation Of Immune System Process Defense Response Vitamin K Metabolic Process Blood Coagulation Hemostasis Negative Regulation Of Complement Activation Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Immune System Process Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Fibrinolysis Response To Wounding Regulation Of Complement Activation Negative Regulation Of Innate Immune Response Quinone Metabolic Process Drug Metabolic Process Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Platelet Degranulation Cellular Ketone Metabolic Process Response To Stimulus Regulation Of Blood Coagulation Vitamin Metabolic Process Negative Regulation Of Immune Response Regulation Of Wound Healing
Tagcloud ?		2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields
Tagcloud (Difference) ?		2j aif1 amd bioinformatic bxd c1qg c1qtnf5 c4b casp1 cd74 cfb cfi coregulated crush dataset datasets efemp1 genenetwork hosted hta1 icam1 illumina inbred interrogate mcdr2 onc ri tgfbr2 wg	c2 c4 c4b2a c5 chains cleaved complement composed eac14gp eac14hu eac14mo fifth filtration fourth fragments functionally glycol homogeneous iodination mol page polyethylene polypeptide precipitation purification purified sds wts yields
Tagcloud (Intersection) ?