SERPING1 and C1S

Number of citations: 28 (PubMedID 6604523)
Data Source: HPRD (in vivo, in vitro)

		SERPING1	C1S
Name		serpin family G member 1	complement C1s
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Blood Microparticle Symbiont Cell Surface
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis Blood Circulation Fibrinolysis	Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		PPL-100 Copper	Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form Sutimlimab
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Mean platelet volume ( 32888494 ) Neuroticism ( 29255261 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Schizophrenia ( 25056061 29483656 )	Activated partial thromboplastin time ( 29403010 ) Alzheimer's disease ( 33654092 ) Coronary artery disease ( 29212778 33020668 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Lung cancer in never smokers ( 28604730 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell fatty acid levels ( 25500335 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 )
Novel Interactors		None recorded	1 novel interactors: IMPDH2
Interacting Genes		17 interacting genes: BAG6 C1R C1S CFTR ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	6 interacting genes: C1QA C1R PKNOX1 REEP4 SERPING1 VKORC1
Entrez ID		710	716
HPRD ID		06033	00397
Ensembl ID		ENSG00000149131	ENSG00000182326
Uniprot IDs		E9KL26 P05155	F8WCZ6 P09871
PDB IDs		2OAY 5DU3 5DUQ 7AKV 8W18	1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H 8GMN 8TYP
GO Terms Enriched among Interactors		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Response To External Biotic Stimulus Zymogen Activation Activation Of Membrane Attack Complex Immune System Process Killing Of Cells Of Another Organism Opsonization Symbiont Cell Surface Peptidase Activity Extracellular Space Protein Processing Response To Other Organism Response To Stress Cell Killing Cell Surface Positive Regulation Of Leukocyte Tethering Or Rolling Defense Response Positive Regulation Of Immune System Process Negative Regulation Of Fibrinolysis Complement Activation Regulation Of Leukocyte Tethering Or Rolling Protein Maturation Proteolysis Regulation Of Fibrinolysis Fibrinolysis Immune Effector Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Immune Response Activation Of Immune Response Positive Regulation Of Blood Coagulation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Coagulation Defense Response To Symbiont Humoral Immune Response Defense Response To Other Organism Complement Activation, Classical Pathway Blood Microparticle Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Lipopolysaccharide Binding Trans-synaptic Signaling By BDNF Regulation Of Immune System Process Extracellular Region Biological Process Involved In Interaction With Symbiont Hydrolase Activity Complement Component C1 Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Cell Migration Negative Regulation Of Blood Coagulation	Complement Component C1 Complex Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Coagulation Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis IMP Dehydrogenase Activity Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Microparticle Leukocyte Activation Complement Component C1q Complex Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Activation IgM Binding Extrinsic Component Of Postsynaptic Membrane 'de Novo' XMP Biosynthetic Process Immune System Process Synapse Pruning GTP Biosynthetic Process Quinone Binding Mitotic Nuclear Membrane Reassembly Extracellular Region Regulation Of Immune Response Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Negative Regulation Of Complement Activation Neuron Remodeling Humoral Immune Response IgG Binding Activation Of Membrane Attack Complex GMP Biosynthetic Process Peptidyl-glutamic Acid Modification Vitamin K Metabolic Process Molecular Sequestering Activity Opsonization Astrocyte Activation Fibrinolysis Purine Ribonucleoside Monophosphate Biosynthetic Process GTP Metabolic Process Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Regulation Of Complement Activation Nuclear Envelope Organization