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SERPING1 and NR4A1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
SERPING1
NR4A1
Description
serpin family G member 1
nuclear receptor subfamily 4 group A member 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Nuclear Speck
Nuclear Membrane
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Peptidase Inhibitor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Lipopolysaccharide Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Nuclear Glucocorticoid Receptor Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Complement Activation, Lectin Pathway
Blood Coagulation
Hemostasis
Blood Circulation
Fibrinolysis
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Apoptotic Process
Inflammatory Response
Signal Transduction
Intracellular Receptor Signaling Pathway
Detection Of Lipopolysaccharide
Endothelial Cell Chemotaxis
Skeletal Muscle Cell Differentiation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Macrophage Activation
Positive Regulation Of Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Fat Cell Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Corticotropin-releasing Hormone Stimulus
Non-canonical Inflammasome Complex Assembly
Pathways
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Defective SERPING1 causes hereditary angioedema
Regulation of Complement cascade
AKT phosphorylates targets in the nucleus
Nuclear Receptor transcription pathway
Constitutive Signaling by AKT1 E17K in Cancer
Drugs
PPL-100
Copper
Diseases
Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
Hereditary angioedema
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Mean platelet volume (
32888494
)
Neuroticism (
29255261
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
17 interacting genes:
BAG6
C1R
C1S
CFTR
ELANE
ENO1
F2
HSP90AA1
MASP1
MASP2
NR4A1
PLAT
PLG
SELE
SELP
SLC30A2
SRPK2
86 interacting genes:
ABCA5
ABCB11
ABCC13
ABCC6
ABCG8
AKT1
ANKIB1
ARHGEF10L
ARHGEF5
ATM
ATXN1
BBS10
BCL2
BCL2A1
BCL2L10
CD2AP
CDKN2D
CHD1L
CHD3
CHEK2
CPT1A
CUTA
DIABLO
EP300
FAF1
FXYD3
GADD45GIP1
GK
GLOD4
GLUD1
HADHA
HES1
HIF1A
HNRNPA2B1
HSP90AB1
KAT2B
KRTAP10-1
KRTAP10-5
LONRF1
LSS
MAP3K1
MAPK1
MAPK8
MED1
MED31
NACAD
NCOA1
NCOA2
NCOA3
NCOR2
NDRG1
NFKB1
NR3C1
PGBD1
PML
POLA2
PPARG
PPBP
PPM1A
PRDX4
PRDX6
RBL1
ROBO2
RPL7
RPS6KA1
RPS6KA3
RPS6KA5
RPS6KA6
RTN4
RXRA
RXRG
SERPINA4
SERPING1
SOCS4
STAT3
SUGT1
TCF4
TP53
TRAF2
TRIM28
TUBB4A
VASP
VHL
YWHAZ
ZNF331
ZNF579
Entrez ID
710
3164
HPRD ID
06033
00744
Ensembl ID
ENSG00000149131
ENSG00000123358
Uniprot IDs
E9KL26
P05155
F5GXF0
P22736
Q6ZMM6
PDB IDs
2OAY
5DU3
5DUQ
7AKV
8W18
2QW4
3V3E
3V3Q
4JGV
4KZI
4KZJ
4KZM
4RE8
4REE
4REF
4RZE
4RZF
4RZG
4WHF
4WHG
6KZ5
6LC1
8WUY
8Y7L
Enriched GO Terms of Interacting Partners
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Serine-type Peptidase Activity
Serine-type Endopeptidase Activity
Response To External Biotic Stimulus
Zymogen Activation
Activation Of Membrane Attack Complex
Immune System Process
Killing Of Cells Of Another Organism
Opsonization
Symbiont Cell Surface
Peptidase Activity
Extracellular Space
Protein Processing
Response To Other Organism
Response To Stress
Cell Killing
Cell Surface
Positive Regulation Of Leukocyte Tethering Or Rolling
Defense Response
Positive Regulation Of Immune System Process
Negative Regulation Of Fibrinolysis
Complement Activation
Regulation Of Leukocyte Tethering Or Rolling
Protein Maturation
Proteolysis
Regulation Of Fibrinolysis
Fibrinolysis
Immune Effector Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Immune Response
Activation Of Immune Response
Positive Regulation Of Blood Coagulation
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Positive Regulation Of Coagulation
Defense Response To Symbiont
Humoral Immune Response
Defense Response To Other Organism
Complement Activation, Classical Pathway
Blood Microparticle
Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Regulation Of Cellular Extravasation
Lipopolysaccharide Binding
Trans-synaptic Signaling By BDNF
Regulation Of Immune System Process
Extracellular Region
Biological Process Involved In Interaction With Symbiont
Hydrolase Activity
Complement Component C1 Complex
Neutrophil-mediated Killing Of Gram-negative Bacterium
Cell Migration
Negative Regulation Of Blood Coagulation
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
TOR Signaling
Positive Regulation Of RNA Metabolic Process
TORC1 Signaling
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Intracellular Receptor Signaling Pathway
Response To Lipid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Nuclear Receptor-mediated Signaling Pathway
Nuclear Receptor Binding
Ubiquitin Protein Ligase Binding
Programmed Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cell Death
Positive Regulation Of Biosynthetic Process
Protein-containing Complex
Cellular Response To Stress
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Small Molecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
Apoptotic Process
Negative Regulation Of Programmed Cell Death
Nucleoplasm
Intrinsic Apoptotic Signaling Pathway
Response To Nutrient Levels
Identical Protein Binding
MRNA Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Apoptotic Process
Regulation Of Protein Stability
Response To Decreased Oxygen Levels
Negative Regulation Of RNA Metabolic Process
Response To Hormone
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Developmental Process
Response To Oxygen Levels
MRNA Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Primary Metabolic Process
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Tagcloud (Intersection)
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