ELANE and SERPINE1

Number of citations of the paper that reports this interaction (PubMedID 7521069)
0

Data Source:
HPRD (in vitro)

		ELANE	SERPINE1
Description		elastase, neutrophil expressed	serpin family E member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Serine Protease Inhibitor Complex Peptidase Inhibitor Complex
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Angiogenesis Response To Bacterium Negative Regulation Of Plasminogen Activation Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Fibrinolysis Positive Regulation Of Angiogenesis Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Positive Regulation Of Coagulation Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Replicative Senescence Dentinogenesis Positive Regulation Of Odontoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Integrin-mediated Signaling Pathway
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes	Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs		Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid	Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone Colforsin Fibrinolysin Copper Bucladesine
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Inherited thrombophilia
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Nonunion in individuals with fractures ( 30680360) Plasma plasminogen activator levels ( 24578379) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Interacting Genes		31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	25 interacting genes: ACTN4 ELANE F2 HSD17B11 IGFBP5 KLK2 KRT18 LMNA LRP1 LRP1B LRP2 MMP3 ORM1 PITX1 PLAT PLAU PLG SGTA SGTB TLX3 TMEM237 UBQLN1 UBQLN2 UBQLN4 VTN
Entrez ID		1991	5054
HPRD ID		00554	01418
Ensembl ID		ENSG00000197561	ENSG00000106366
Uniprot IDs		P08246	B7ZAB0 P05121
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU	1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 4G8O 4G8R 4IC0 5BRR 5ZLZ 6GWN 6GWP 6GWQ 6I8S 6ZRV 7AQF 7AQG 9PAI
Enriched GO Terms of Interacting Partners?		Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinolysis Serine-type Peptidase Activity Positive Regulation Of Wound Healing Regulation Of Proteolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Proteolysis Regulation Of Protein Metabolic Process Low-density Lipoprotein Particle Receptor Activity Regulation Of Wound Healing Negative Regulation Of Proteolysis TRC Complex Positive Regulation Of ERAD Pathway Peptidase Activity Extracellular Space Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of ERAD Pathway Regulation Of Cell Migration Endopeptidase Activity Regulation Of Cell Motility Trans-synaptic Signaling By BDNF Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Locomotion Blood Coagulation Coagulation Neutrophil-mediated Killing Of Gram-negative Bacterium Hemostasis Positive Regulation Of Lysosomal Protein Catabolic Process Serine Protease Inhibitor Complex Biological Process Involved In Interaction With Symbiont Zymogen Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Response To Endoplasmic Reticulum Stress Extracellular Matrix Blood Microparticle Negative Regulation Of Multicellular Organismal Process
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