ELANE and CSF3

Number of citations of the paper that reports this interaction (PMID 14587040)
8

Data Source:
HPRD (in vitro)

		ELANE	CSF3
Gene Name		elastase, neutrophil expressed	colony stimulating factor 3 (granulocyte)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome	Extracellular Space
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus	Immune Response Multicellular Organismal Development Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS			Neutrophil count ( 20172861) White blood cell count ( 20139978 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS	2 interactors: CSF3R ELANE
Entrez ID		1991	1440
HPRD ID		00554	00736
Ensembl ID		ENSG00000197561	ENSG00000108342
Uniprot IDs		P08246	P09919 Q6FH65 Q8N4W3
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77	1CD9 1GNC 1PGR 1RHG 2D9Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation	Leukocyte Migration Neutrophil Mediated Killing Of Fungus Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Acute Inflammatory Response To Antigenic Stimulus Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Interleukin-8 Production Amelogenesis Cell Migration Cell Motility Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemotaxis Defense Response To Fungus Positive Regulation Of Interleukin-8 Production Interaction With Symbiont Leukocyte Mediated Cytotoxicity Inflammatory Response To Antigenic Stimulus Locomotion Negative Regulation Of Cytokine Biosynthetic Process Defense Response Response To Fungus Movement Of Cell Or Subcellular Component Neutrophil Chemotaxis Neutrophil Migration Regulation Of Chemokine Production Granulocyte Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Collagen Catabolic Process Positive Regulation Of Cytokine Biosynthetic Process Response To External Stimulus Acute Inflammatory Response Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Immune System Process Regulation Of Smooth Muscle Cell Proliferation Leukocyte Chemotaxis Negative Regulation Of Inflammatory Response Odontogenesis Of Dentin-containing Tooth Regulation Of Cytokine Biosynthetic Process Odontogenesis Response To UV Response To Organic Substance Regulation Of Chemotaxis
Tagcloud ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	bioinformatics bmp2 calm1 cnaq csf2rb expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	bioinformatics bmp2 calm1 cnaq csf2rb expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?