ELANE and F2R

Number of citations of the paper that reports this interaction (PMID 10978167)
15

Data Source:
HPRD (in vitro)

		ELANE	F2R
Gene Name		elastase, neutrophil expressed	coagulation factor II (thrombin) receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome	Extracellular Region Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Receptor Binding Protein Binding Thrombin Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus	Activation Of MAPKK Activity Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JAK-STAT Cascade Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Platelet Dense Granule Organization Positive Regulation Of ERK1 And ERK2 Cascade Thrombin Receptor Signaling Pathway Negative Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) Common Pathway G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818	Streptokinase
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS	17 interactors: ATP13A2 CAPN1 CHRD CTSG ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNX1
Entrez ID		1991	2149
HPRD ID		00554	01763
Ensembl ID		ENSG00000197561	ENSG00000181104
Uniprot IDs		P08246	P25116 Q2TNB2
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Extracellular Matrix Disassembly Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Killing By Host Of Symbiont Cells Leukocyte Migration Receptor Metabolic Process Negative Regulation Of Fibrinolysis Response To Stress Receptor Catabolic Process Regulation Of Fibrinolysis Proteolysis G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Locomotion Cellular Homeostasis Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Cellular Metal Ion Homeostasis Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Regulation Of Cell Shape Fibrinolysis Cellular Cation Homeostasis Positive Regulation Of Blood Coagulation Cellular Ion Homeostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Interaction With Symbiont Leukocyte Mediated Cytotoxicity Cytosolic Calcium Ion Homeostasis Metal Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Coagulation Response To Fungus Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Response To Stimulus Positive Regulation Of Wound Healing Ion Homeostasis
Tagcloud ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
Tagcloud (Difference) ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
Tagcloud (Intersection) ?