ELANE and TGFA

Number of citations of the paper that reports this interaction (PMID 15245434)
7

Data Source:
HPRD (in vitro)

		ELANE	TGFA
Gene Name		elastase, neutrophil expressed	transforming growth factor, alpha
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome	Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Glycoprotein Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus	Activation Of MAPK Activity Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Wound Healing Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Mammary Gland Alveolus Development
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS			Longevity ( 20834067) Neutrophil count ( 21507922) Obesity-related traits ( 23251661)
Protein-Protein Interactions		30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS	15 interactors: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 MAGI2 MAGI3 NKD2 RHBDF1 SDCBP SGTA SNTA1
Entrez ID		1991	7039
HPRD ID		00554	07522
Ensembl ID		ENSG00000197561	ENSG00000163235
Uniprot IDs		P08246	E7EPT6 F8VNR3 P01135
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77	1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway Locomotion Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component PMA-inducible Membrane Protein Ectodomain Proteolysis Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Cell Migration Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Collagen Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of T Cell Chemotaxis Regulation Of Cell Proliferation Collagen Metabolic Process Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Multicellular Organismal Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Generation Of Neurons Regulation Of Cell Migration Multicellular Organismal Metabolic Process
Tagcloud ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing
Tagcloud (Difference) ?		absent anomalies congenital deceased describes eight eleven far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfb3 thra1 transforming transmission trios utilizing
Tagcloud (Intersection) ?		ethnic