ELANE and SERPINB1

Number of citations of the paper that reports this interaction (PMID 10924364)
1

Data Source:
HPRD (in vitro)

		ELANE	SERPINB1
Gene Name		elastase, neutrophil expressed	serpin peptidase inhibitor, clade B (ovalbumin), member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus	Negative Regulation Of Endopeptidase Activity
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS
Protein-Protein Interactions		30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS	3 interactors: ELANE PRTN3 XPO1
Entrez ID		1991	1992
HPRD ID		00554	00555
Ensembl ID		ENSG00000197561	ENSG00000021355
Uniprot IDs		P08246	P30740
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77	4GA7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation	Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Neutrophil Mediated Killing Of Fungus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Mature Conventional Dendritic Cell Differentiation Ribosomal Large Subunit Export From Nucleus Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Ribosomal Subunit Export From Nucleus Acute Inflammatory Response To Antigenic Stimulus Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Phagocytosis Negative Regulation Of Interleukin-8 Production Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemotaxis Defense Response To Fungus Intracellular Transport Of Virus Positive Regulation Of Cell Proliferation Positive Regulation Of Interleukin-8 Production Protein Export From Nucleus Interaction With Symbiont Inflammatory Response To Antigenic Stimulus Leukocyte Mediated Cytotoxicity Regulation Of Centrosome Duplication Negative Regulation Of Cytokine Biosynthetic Process Dendritic Cell Differentiation Response To Fungus Regulation Of Centrosome Cycle Negative Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chemokine Production Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Phagocytosis Positive Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Acute Inflammatory Response Regulation Of Cell Proliferation
Tagcloud ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	a431 a431cells allowing annotation apoptotic components cytochrome cytoskeletal dnaaseii egf epidermoid evenly exploited modeled networks overexpress proteome proteomic proteomics signalling split stream sub suppressors tp53 trigger triggering undergo unlikely
Tagcloud (Difference) ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	a431 a431cells allowing annotation apoptotic components cytochrome cytoskeletal dnaaseii egf epidermoid evenly exploited modeled networks overexpress proteome proteomic proteomics signalling split stream sub suppressors tp53 trigger triggering undergo unlikely
Tagcloud (Intersection) ?