ELANE and YARS

Number of citations of the paper that reports this interaction (PMID 10102815)
85

Data Source:
HPRD (in vitro)

		ELANE	YARS
Gene Name		elastase, neutrophil expressed	tyrosyl-tRNA synthetase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	TRNA Binding Isoleucine-tRNA Ligase Activity Tyrosine-tRNA Ligase Activity Signal Transducer Activity Interleukin-8 Receptor Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus	TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Tyrosyl-tRNA Aminoacylation Apoptotic Process Signal Transduction Gene Expression
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818	L-Tyrosine Beta-(2-Naphthyl)-Alanine Tyrosinal N6-ISOPENTENYL-ADENOSINE-5\'-MONOPHOSPHATE PARA-(BENZOYL)-PHENYLALANINE 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
Diseases
GWAS
Protein-Protein Interactions		30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS	1 interactors: ELANE
Entrez ID		1991	8565
HPRD ID		00554	09153
Ensembl ID		ENSG00000197561	ENSG00000134684
Uniprot IDs		P08246	P54577
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77	1N3L 1NTG 1Q11
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation	Neutrophil Mediated Killing Of Fungus Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Acute Inflammatory Response To Antigenic Stimulus Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Interleukin-8 Production Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemotaxis Defense Response To Fungus Positive Regulation Of Interleukin-8 Production Interaction With Symbiont Leukocyte Mediated Cytotoxicity Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Regulation Of Chemokine Production Positive Regulation Of Smooth Muscle Cell Proliferation Collagen Catabolic Process Positive Regulation Of Cytokine Biosynthetic Process Acute Inflammatory Response Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Cytokine Biosynthetic Process Response To UV Regulation Of Chemotaxis Regulation Of Behavior Defense Response To Bacterium Negative Regulation Of Cytokine Production Positive Regulation Of MAP Kinase Activity Leukocyte Migration Negative Regulation Of Growth Negative Regulation Of Locomotion Phagocytosis Leukocyte Mediated Immunity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Inflammatory Response Regulation Of MAP Kinase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin
Tagcloud ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	abnormal accordingly anergy ciita class classical constitutive deregulation displaying dissemination dr escape fibroblast histocompatibility hla isoform lymphocyte melanocytes melanoma melanomas mhc participate synthetase transactivator transforming trip1 trna tumour tyrosyl
Tagcloud (Difference) ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	abnormal accordingly anergy ciita class classical constitutive deregulation displaying dissemination dr escape fibroblast histocompatibility hla isoform lymphocyte melanocytes melanoma melanomas mhc participate synthetase transactivator transforming trip1 trna tumour tyrosyl
Tagcloud (Intersection) ?