ELANE and YARS1

Number of citations of the paper that reports this interaction (PubMedID 10102815)
0

Data Source:
HPRD (in vitro)

		ELANE	YARS1
Description		elastase, neutrophil expressed	tyrosyl-tRNA synthetase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol Nuclear Body
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding	TRNA Binding Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Tyrosine-tRNA Ligase Activity Interleukin-8 Receptor Binding Protein Binding ATP Binding Ligase Activity Small Molecule Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Translation TRNA Aminoacylation For Protein Translation Tyrosyl-tRNA Aminoacylation Apoptotic Process Response To Stress Response To Starvation Protein Poly-ADP-ribosylation
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes	Cytosolic tRNA aminoacylation
Drugs		Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid	Tyrosine Beta-(2-Naphthyl)-Alanine Resveratrol Tyrosinal N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE p-Benzoyl-L-phenylalanine 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood protein levels ( 30072576)
Interacting Genes		31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	6 interacting genes: CDC42 ELANE ESR1 OGT REL USP25
Entrez ID		1991	8565
HPRD ID		00554	09153
Ensembl ID		ENSG00000197561	ENSG00000134684
Uniprot IDs		P08246	A0A0S2Z4R1 P54577
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU	1N3L 1NTG 1Q11 4Q93 4QBT 5THH 5THL 7ROU
Enriched GO Terms of Interacting Partners?		Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Pyroptotic Inflammatory Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phagocytic Vesicle Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Negative Regulation Of Gene Expression ATPase Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Negative Regulation Of Protein-containing Complex Assembly Storage Vacuole Cytosol Antibacterial Peptide Biosynthetic Process Negative Regulation Of Metabolic Process Inflammatory Response Neutrophil-mediated Killing Of Fungus Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Apolipoprotein A-I Receptor Binding Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Neuropilin Signaling Pathway Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth NF-kappaB Complex Protein-containing Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Ubiquitin-like Protein Peptidase Activity Non-canonical Inflammasome Complex Assembly Regulation Of Proteasomal Protein Catabolic Process
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