ELANE and SERPIND1

Number of citations of the paper that reports this interaction (PMID 2318847)
8

Data Source:
HPRD (in vitro, in vivo)

		ELANE	SERPIND1
Gene Name		elastase, neutrophil expressed	serpin peptidase inhibitor, clade D (heparin cofactor), member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Heparin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus	Chemotaxis Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818	Ardeparin Alpha-D-Mannose Sulodexide
Diseases
GWAS
Protein-Protein Interactions		30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS	4 interactors: APP CTSG ELANE F2
Entrez ID		1991	3053
HPRD ID		00554	00795
Ensembl ID		ENSG00000197561	ENSG00000099937
Uniprot IDs		P08246	P05546 Q8IVC0
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77	1JMJ 1JMO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation	Killing By Host Of Symbiont Cells Regulation Of Growth Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Defense Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Extracellular Matrix Organization Extracellular Structure Organization Response To Fungus Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Acute Inflammatory Response Immune System Process Regulation Of Protein Metabolic Process Extracellular Matrix Disassembly Cellular Homeostasis Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Negative Regulation Of Protein Metabolic Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Synaptic Growth At Neuromuscular Junction Regulation Of Protein Phosphorylation Defense Response To Bacterium Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Collateral Sprouting In Absence Of Injury Leukocyte Migration Positive Regulation Of Protein Metabolic Process Locomotion Negative Regulation Of Growth Immune Response Regulation Of Phosphorylation Leukocyte Mediated Immunity Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Neurogenesis
Tagcloud ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Difference) ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Intersection) ?