ITGA2B

Description		integrin subunit alpha 2b
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Platelet Alpha Granule Membrane Extracellular Exosome Integrin AlphaIIb-beta3 Complex Blood Microparticle
	Molecular Function	Protein Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Molecular Adaptor Activity Fibrinogen Binding
	Biological Process	Angiogenesis Positive Regulation Of Leukocyte Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Adhesion
Pathways		Platelet degranulation Integrin cell surface interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Abciximab Tirofiban Lefradafiban Fradafiban
Diseases		Glanzmann thrombasthenia
GWAS		Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 27863252 32888494) Platelet count ( 22139419 27863252 32888494) Platelet distribution width ( 27863252) Plateletcrit ( 32888494)
Interacting Genes		21 interacting genes: APP AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA FGG FN1 GRB2 ITGB3 PLA2G4A PRKACA SHARPIN TLN1 VTN VWF
Entrez ID		3674
HPRD ID		06377
Ensembl ID		ENSG00000005961
Uniprot IDs		P08514
PDB IDs		1DPK 1DPQ 1KUP 1KUZ 1M8O 1S4W 1TYE 2K1A 2K9J 2KNC 2MTP 2N9Y 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4Z7N 4Z7O 4Z7Q 5HDB 6V4P 7KN0 7L8P 7LA4 7SC4 7SFT 7TCT 7TD8 7THO 7TMZ 7TPD 7U60 7U9F 7U9V 7UBR 7UCY 7UDG 7UDH 7UE0 7UFH 7UH8 7UJE 7UJK 7UK9 7UKO 7UKP 7UKT 8GCD 8GCE 8T2U 8T2V 9AXL 9DEQ 9DER
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Adhesion Extracellular Matrix Structural Constituent Positive Regulation Of Signal Transduction Blood Coagulation, Fibrin Clot Formation Integrin Binding Extracellular Exosome Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Body Fluid Levels Positive Regulation Of Intracellular Signal Transduction Endoplasmic Reticulum Lumen Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Blood Coagulation Coagulation Positive Regulation Of Cell Adhesion Hemostasis Platelet Alpha Granule Regulation Of Signal Transduction Protein Activation Cascade Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Biological Quality Regulation Of Cell Adhesion Platelet Alpha Granule Lumen Positive Regulation Of Transport Platelet Activation Extracellular Matrix Regulation Of Blood Coagulation Cell Adhesion Regulation Of Hemostasis Cell-substrate Adhesion Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Fibrinogen Complex External Side Of Plasma Membrane Regulation Of Vesicle-mediated Transport Cell-matrix Adhesion Extracellular Space Blood Microparticle Negative Regulation Of Blood Coagulation Platelet Aggregation Negative Regulation Of Hemostasis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Coagulation Regulation Of Protein Localization Regulation Of Transport
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