Wiki-Pi
About
Search
People
Updates
Search
ITGA2B and FGA
Number of citations of the paper that reports this interaction (PubMedID
11460491
)
0
Data Source:
HPRD
(in vitro)
ITGA2B
FGA
Description
integrin subunit alpha 2b
fibrinogen alpha chain
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Platelet Alpha Granule Membrane
Extracellular Exosome
Integrin AlphaIIb-beta3 Complex
Blood Microparticle
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Extracellular Vesicle
Molecular Function
Protein Binding
Signaling Receptor Activity
Identical Protein Binding
Metal Ion Binding
Extracellular Matrix Binding
Molecular Adaptor Activity
Fibrinogen Binding
Signaling Receptor Binding
Structural Molecule Activity
Extracellular Matrix Structural Constituent
Protein Binding
Protein-macromolecule Adaptor Activity
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Angiogenesis
Positive Regulation Of Leukocyte Migration
Cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Cell-cell Adhesion
Adaptive Immune Response
Immune System Process
Cell-matrix Adhesion
Blood Coagulation
Hemostasis
Platelet Activation
Plasminogen Activation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Fibrinolysis
Induction Of Bacterial Agglutination
Innate Immune Response
Positive Regulation Of Vasoconstriction
Positive Regulation Of Exocytosis
Positive Regulation Of Protein Secretion
Protein Polymerization
Response To Calcium Ion
Protein-containing Complex Assembly
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Blood Coagulation, Common Pathway
Blood Coagulation, Fibrin Clot Formation
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Coagulation, Common Pathway
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Platelet degranulation
Integrin cell surface interactions
ECM proteoglycans
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Signal transduction by L1
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Platelet degranulation
ER-Phagosome pathway
Common Pathway of Fibrin Clot Formation
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Integrin cell surface interactions
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Amyloid fiber formation
Drugs
Abciximab
Tirofiban
Lefradafiban
Fradafiban
Alteplase
Reteplase
Anistreplase
Tenecteplase
Sucralfate
Zinc
Alfimeprase
Ancrod
EP-2104R
Lanoteplase
Thrombin
Prothrombin
Human thrombin
Thrombin alfa
Anti-inhibitor coagulant complex
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Glanzmann thrombasthenia
Familial amyloidosis
Inherited thrombophilia
Afibrinogenemia; Dysfibrinogenemia
GWAS
Brain morphology (MOSTest) (
32665545
)
Mean platelet volume (
27863252
32888494
)
Platelet count (
22139419
27863252
32888494
)
Platelet distribution width (
27863252
)
Plateletcrit (
32888494
)
D-dimer levels (
21502573
)
Fibrinogen (
20031577
21757653
)
Venous thromboembolism (
21980494
30659681
33592630
)
Interacting Genes
21 interacting genes:
APP
AUP1
CALR
CAMK2A
CD36
CIB1
CLNS1A
COL1A2
COL2A1
F2
FGA
FGG
FN1
GRB2
ITGB3
PLA2G4A
PRKACA
SHARPIN
TLN1
VTN
VWF
30 interacting genes:
AGTRAP
APP
CDH5
EXOC5
F13A1
F2
FGB
FGG
HRG
HSP90AA1
ITGA2B
ITGB3
LRP1B
MEOX2
NID1
PLAT
PRRC2A
SERPINA5
SERPINF2
SH3BP1
STX1B
STX2
SYCE1L
TFIP11
THBS1
TMEM43
TPM1
TPM3
UBC
VWF
Entrez ID
3674
2243
HPRD ID
06377
00619
Ensembl ID
ENSG00000005961
ENSG00000171560
Uniprot IDs
P08514
P02671
PDB IDs
1DPK
1DPQ
1KUP
1KUZ
1M8O
1S4W
1TYE
2K1A
2K9J
2KNC
2MTP
2N9Y
2VC2
2VDK
2VDL
2VDM
2VDN
2VDO
2VDP
2VDQ
2VDR
3FCS
3FCU
3NID
3NIF
3NIG
3T3M
3T3P
3ZDX
3ZDY
3ZDZ
3ZE0
3ZE1
3ZE2
4CAK
4Z7N
4Z7O
4Z7Q
5HDB
6V4P
7KN0
7L8P
7LA4
7SC4
7SFT
7TCT
7TD8
7THO
7TMZ
7TPD
7U60
7U9F
7U9V
7UBR
7UCY
7UDG
7UDH
7UE0
7UFH
7UH8
7UJE
7UJK
7UK9
7UKO
7UKP
7UKT
8GCD
8GCE
8T2U
8T2V
9AXL
9DEQ
9DER
1BBR
1DM4
1FPH
1FZA
1FZB
1FZC
1FZD
1FZE
1FZF
1FZG
1LT9
1LTJ
1N86
1N8E
1RE3
1RE4
1RF0
1RF1
1YCP
2A45
2FFD
2H43
2HLO
2HOD
2HPC
2OYH
2OYI
2Q9I
2XNX
2XNY
2Z4E
3AT0
3BVH
3E1I
3GHG
3H32
3HUS
4F27
5CFA
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Cell-substrate Adhesion
Extracellular Matrix Structural Constituent
Positive Regulation Of Signal Transduction
Blood Coagulation, Fibrin Clot Formation
Integrin Binding
Extracellular Exosome
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Body Fluid Levels
Positive Regulation Of Intracellular Signal Transduction
Endoplasmic Reticulum Lumen
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Blood Coagulation
Coagulation
Positive Regulation Of Cell Adhesion
Hemostasis
Platelet Alpha Granule
Regulation Of Signal Transduction
Protein Activation Cascade
Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Biological Quality
Regulation Of Cell Adhesion
Platelet Alpha Granule Lumen
Positive Regulation Of Transport
Platelet Activation
Extracellular Matrix
Regulation Of Blood Coagulation
Cell Adhesion
Regulation Of Hemostasis
Cell-substrate Adhesion
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Fibrinogen Complex
External Side Of Plasma Membrane
Regulation Of Vesicle-mediated Transport
Cell-matrix Adhesion
Extracellular Space
Blood Microparticle
Negative Regulation Of Blood Coagulation
Platelet Aggregation
Negative Regulation Of Hemostasis
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Coagulation
Regulation Of Protein Localization
Regulation Of Transport
Platelet Alpha Granule Lumen
Platelet Alpha Granule
Fibrinolysis
Blood Coagulation, Fibrin Clot Formation
Extracellular Matrix
Negative Regulation Of Fibrinolysis
Coagulation
Blood Coagulation
Hemostasis
Regulation Of Blood Coagulation
Regulation Of Body Fluid Levels
Regulation Of Hemostasis
Regulation Of Fibrinolysis
Protein Activation Cascade
Negative Regulation Of Blood Coagulation
Fibrinogen Binding
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Fibrinogen Complex
Positive Regulation Of Blood Coagulation
Extracellular Exosome
Blood Microparticle
Positive Regulation Of Coagulation
Platelet Activation
Negative Regulation Of Wound Healing
Regulation Of Wound Healing
External Side Of Plasma Membrane
Cell Surface
Regulation Of Response To Wounding
Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Wound Healing
Negative Regulation Of Plasminogen Activation
Extracellular Matrix Binding
Cell-substrate Adhesion
Regulation Of Biological Quality
Signaling Receptor Binding
Negative Regulation Of Endothelial Cell Apoptotic Process
Plasminogen Activation
Cell-matrix Adhesion
Protease Binding
Extracellular Matrix Structural Constituent
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Plasminogen Activation
Extracellular Space
Negative Regulation Of Protein Processing
Heparin Binding
Integrin AlphaIIb-beta3 Complex
Negative Regulation Of Protein Maturation
Membrane Organization
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?