ITGA2B and CIB1

Number of citations of the paper that reports this interaction (PMID 9030514)
54

Data Source:
HPRD (in vitro, two hybrid)

		ITGA2B	CIB1
Gene Name		integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	calcium and integrin binding 1 (calmyrin)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Vesicular Exosome Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding	Calcium Ion Binding Protein Binding Ras GTPase Binding Protein Anchor Ion Channel Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Platelet Activation Extracellular Matrix Organization Platelet Aggregation	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Metalloenzyme Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways		Signal transduction by L1 Axon guidance p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Abciximab Tirofiban
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		15 interactors: AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA GRB2 ITGB3 PRKACA TLN1 VWF	21 interactors: AURKB CDK4 EXOSC10 FEZ1 IFI6 ITGA2B ITGB3 NBR1 NRIP1 PAX3 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 TERT UBR5 WAS ZDHHC17
Entrez ID		3674	10519
HPRD ID		06377	03800
Ensembl ID		ENSG00000005961
Uniprot IDs		P08514	H6WJF3 Q99828
PDB IDs		1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Platelet Degranulation Response To Stress Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Leukocyte Migration Cellular Response To Organic Substance Cellular Component Assembly Regulation Of Blood Coagulation Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Signaling Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Phosphorylation Exocytosis Positive Regulation Of Cellular Protein Metabolic Process Platelet Aggregation Cell Adhesion Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Cardiovascular System Development Positive Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Transport Secretion By Cell Movement Of Cell Or Subcellular Component	Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cell Death Homotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Negative Regulation Of Cell Death Cell Activation Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Neuron Differentiation Generation Of Neurons Developmental Process Single Organismal Cell-cell Adhesion Signaling Neurogenesis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Binding Nervous System Development Cell Development Neuron Development Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Component Organization Axon Guidance Organelle Organization Cell Death Movement Of Cell Or Subcellular Component Death Positive Regulation Of Cellular Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Embryo Development Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cell Cycle
Tagcloud ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Difference) ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr	accelerated ask1 ca cytosolic depleting depolarization dysregulation efflux excessive folding homeostasis inactivated influx inositol insp3 insp3r ire1alpha mitochondrion otherwise perturbation posttranslational reservoir secretory sh superoxide sy5y traf2 triggers underlies
Tagcloud (Intersection) ?