ITGA2B and AUP1

Number of citations of the paper that reports this interaction (PMID 12042322)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ITGA2B	AUP1
Gene Name		integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	ancient ubiquitous protein 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Vesicular Exosome Blood Microparticle	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding	Protein Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Platelet Activation Extracellular Matrix Organization Platelet Aggregation
Pathways		Signal transduction by L1 Axon guidance p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Abciximab Tirofiban
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		15 interactors: AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA GRB2 ITGB3 PRKACA TLN1 VWF	7 interactors: ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11
Entrez ID		3674	550
HPRD ID		06377	03892
Ensembl ID		ENSG00000005961	ENSG00000115307
Uniprot IDs		P08514	Q9Y679
PDB IDs		1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2	2EKF
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Platelet Degranulation Response To Stress Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Leukocyte Migration Cellular Response To Organic Substance Cellular Component Assembly Regulation Of Blood Coagulation Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Signaling Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Phosphorylation Exocytosis Positive Regulation Of Cellular Protein Metabolic Process Platelet Aggregation Cell Adhesion Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Cardiovascular System Development Positive Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Transport Secretion By Cell Movement Of Cell Or Subcellular Component	Integrin-mediated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Cell-substrate Adhesion Regulation Of Body Fluid Levels Wound Healing Chemotaxis Response To Wounding Axon Guidance Cell-matrix Adhesion Cell Adhesion Axonogenesis Locomotion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Leukocyte Migration Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Neurogenesis Neuron Projection Development Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Migration Cell Part Morphogenesis Positive Regulation Of Cell Motility Cell Development Response To External Stimulus Positive Regulation Of Cellular Component Movement Cell Motility Positive Regulation Of Locomotion Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Nervous System Development Formation Of Primary Germ Layer Cell Adhesion Mediated By Integrin Single Organismal Cell-cell Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Gastrulation Heterotypic Cell-cell Adhesion Regulation Of Locomotion Generation Of Neurons Regulation Of Cellular Component Movement Cellular Extravasation Positive Regulation Of Phosphatase Activity
Tagcloud ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr	abundance affects ancient associates conjugating connection cue dislocation droplet droplets endoplasmic engagement facilitates hrd1 impairs involves lipid localizes misfolded physically polyubiquitylation proteasome quality recruit reticulum sel1l ube2g2 ubiquitin ubiquitous
Tagcloud (Difference) ?		actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr	abundance affects ancient associates conjugating connection cue dislocation droplet droplets endoplasmic engagement facilitates hrd1 impairs involves lipid localizes misfolded physically polyubiquitylation proteasome quality recruit reticulum sel1l ube2g2 ubiquitin ubiquitous
Tagcloud (Intersection) ?