SDF4 and RAP1B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SDF4	RAP1B
Gene Name		stromal cell derived factor 4	RAP1B, member of RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Late Endosome Golgi Apparatus Golgi Lumen Plasma Membrane Membrane Bleb Extracellular Vesicular Exosome	Intracellular Lipid Particle Cytosol Plasma Membrane Cell-cell Junction Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	UV Protection Calcium Ion-dependent Exocytosis Cerebellum Development Fat Cell Differentiation Response To Ethanol Zymogen Granule Exocytosis	Blood Coagulation Cell Proliferation Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways			Rap1 signalling p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs
Diseases
GWAS			White blood cell count ( 20139978)
Protein-Protein Interactions		12 interactors: ANXA7 APP CDKN1A NR1I2 RAP1B RCC1 RPA2 SMN1 SNCA TK1 TTR ZNF512B	29 interactors: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		51150	5908
HPRD ID		13113	01546
Ensembl ID		ENSG00000078808	ENSG00000127314
Uniprot IDs		Q9BRK5	B7ZAY2 P61224
PDB IDs			3BRW 3CF6 4DXA 4HDO 4HDQ
Enriched GO Terms of Interacting Partners?		Response To Organic Cyclic Compound Negative Regulation Of Neurotransmitter Transport Regulation Of Mitotic Cell Cycle Response To Copper Ion G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Exocytosis Regulation Of Synaptic Vesicle Transport Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Synaptic Transmission Regulation Of Neurotransmitter Secretion Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cellular Response To Heat Response To Metal Ion Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Drug Export Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Fetal Process Involved In Parturition Response To Light Stimulus Positive Regulation Of Catalytic Activity Mitotic G1 DNA Damage Checkpoint Response To Lipid Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Response To Organic Substance Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Cycle Positive Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Organic Cyclic Compound Skeletal Muscle Cell Proliferation Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Synaptic Growth At Neuromuscular Junction Mitotic DNA Damage Checkpoint Hemostasis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Response To External Stimulus Response To Radiation Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Kinase Activity Response To Heat	Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of Phosphorylation Response To Radiation Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Cell Communication Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Negative Regulation Of Hydrolase Activity Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Blood Coagulation Hemostasis Neurotrophin Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Component Organization
Tagcloud ?		3d accessory alignment arabidopsis barrel bottom comprises conservation endoplasmic hydrophobic lacks motifs mus musculus paralogous raised resident sdf1 sdf2 sdf2l1 sdf5 sdfs secretory seem stromal structurally thaliana trefoil unfolded	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Difference) ?		3d accessory alignment arabidopsis barrel bottom comprises conservation endoplasmic hydrophobic lacks motifs mus musculus paralogous raised resident sdf1 sdf2 sdf2l1 sdf5 sdfs secretory seem stromal structurally thaliana trefoil unfolded	adp alphaiibbeta3 alzheimer apyrase atherothrombotic autocrine besides ca2 cerebrovascular collectively complement dense discovered discoveries fibrinogen granule gtpase integrin manage marginal p2y peptides platelet platelets signalling stimulant stimulates syk thrombus
Tagcloud (Intersection) ?