NKIRAS2 and TK1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NKIRAS2	TK1
Gene Name		NFKB inhibitor interacting Ras-like 2	thymidine kinase 1, soluble
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm Membrane	Cytosol
	Molecular Function	GTPase Activity GTP Binding	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling Small GTPase Mediated Signal Transduction	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process
Pathways			Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs			Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		5 interactors: NFKBIA NFKBIB PAX6 SMN1 TK1	159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		28511	7083
HPRD ID		07261	01771
Ensembl ID		ENSG00000168256	ENSG00000167900
Uniprot IDs		Q9NYR9	P04183
PDB IDs			1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Response To Lipid Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Lipid Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Response To External Stimulus Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Fetal Process Involved In Parturition Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Skeletal Muscle Cell Proliferation Positive Regulation Of Glucagon Secretion Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Response To Organic Substance Rhombomere Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Asymmetric Cell Division Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Positive Regulation Of Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Pancreatic A Cell Differentiation Cytoplasmic Sequestering Of NF-kappaB Response To Cortisol Somatic Motor Neuron Differentiation Thymidine Metabolic Process Cellular Response To Cold Forebrain Anterior/posterior Pattern Specification Cerebral Cortex Regionalization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain Dorsal/ventral Pattern Formation	Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus
Tagcloud ?		125b chemoresistance confers confirming conversely develops diffusely discouraging gbm glioblastoma gliomas infiltrating methylguanine methyltransferase mgmt microrna mir neoplasia overexpressing owing prognostically radiotherapy remarkably respond temozolomide tmz tnfaip3 tnfalpha tp53	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Difference) ?		125b chemoresistance confers confirming conversely develops diffusely discouraging gbm glioblastoma gliomas infiltrating methylguanine methyltransferase mgmt microrna mir neoplasia overexpressing owing prognostically radiotherapy remarkably respond temozolomide tmz tnfaip3 tnfalpha tp53	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Intersection) ?