NKIRAS2 and NFKBIB

Number of citations of the paper that reports this interaction (PMID 10657303)
15

Data Source:
HPRD (in vivo, in vitro)

		NKIRAS2	NFKBIB
Gene Name		NFKB inhibitor interacting Ras-like 2	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm Membrane	Nucleus Cytosol
	Molecular Function	GTPase Activity GTP Binding	Transcription Coactivator Activity Signal Transducer Activity Protein Binding
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling Small GTPase Mediated Signal Transduction	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Signal Transduction Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide
Pathways			Signaling by the B Cell Receptor (BCR) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: NFKBIA NFKBIB PAX6 SMN1 TK1	40 interactors: APP BAK1 BTRC CD3EAP CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52
Entrez ID		28511	4793
HPRD ID		07261	07260
Ensembl ID		ENSG00000168256	ENSG00000104825
Uniprot IDs		Q9NYR9	Q15653
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Lipid Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Lipid Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Response To External Stimulus Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Fetal Process Involved In Parturition Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Skeletal Muscle Cell Proliferation Positive Regulation Of Glucagon Secretion Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Response To Organic Substance Rhombomere Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Asymmetric Cell Division Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Positive Regulation Of Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Pancreatic A Cell Differentiation Cytoplasmic Sequestering Of NF-kappaB Response To Cortisol Somatic Motor Neuron Differentiation Thymidine Metabolic Process Cellular Response To Cold Forebrain Anterior/posterior Pattern Specification Cerebral Cortex Regionalization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain Dorsal/ventral Pattern Formation	Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Initiation Positive Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression Regulation Of Cytokine Production Toll-like Receptor 5 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Intracellular Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stimulus Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Regulation Of Protein Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response
Tagcloud ?		125b chemoresistance confers confirming conversely develops diffusely discouraging gbm glioblastoma gliomas infiltrating methylguanine methyltransferase mgmt microrna mir neoplasia overexpressing owing prognostically radiotherapy remarkably respond temozolomide tmz tnfaip3 tnfalpha tp53	abi analyse ctla4 episodes genotyped ikbkb il4ra il8 map3k1 mbl2 polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing
Tagcloud (Difference) ?		125b chemoresistance confers confirming conversely develops diffusely discouraging gbm glioblastoma gliomas infiltrating methylguanine methyltransferase mgmt microrna mir neoplasia overexpressing owing prognostically radiotherapy remarkably respond temozolomide tmz tnfaip3 tnfalpha tp53	abi analyse ctla4 episodes genotyped ikbkb il4ra il8 map3k1 mbl2 polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing
Tagcloud (Intersection) ?