KDM6B

Gene Name		lysine (K)-specific demethylase 6B
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Beta-catenin Binding Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Chromatin Organization Inflammatory Response Endothelial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesodermal Cell Differentiation Cardiac Muscle Cell Differentiation Oxidation-reduction Process Cellular Response To Hydrogen Peroxide Histone H3-K27 Demethylation
Pathways		Chromatin modifying enzymes Chromatin organization Oxidative Stress Induced Senescence HDMs demethylate histones Cellular Senescence
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: CSNK2B HIST1H3A TK1
Entrez ID		23135
HPRD ID		18983
Ensembl ID		ENSG00000132510
Uniprot IDs		O15054
PDB IDs		2XUE 2XXZ 4ASK
Enriched GO Terms of Interacting Partners?		Protein Complex Assembly Fetal Process Involved In Parturition Skeletal Muscle Cell Proliferation Cellular Component Assembly Thymidine Metabolic Process Response To Cortisol Positive Regulation Of Activin Receptor Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process Adiponectin-activated Signaling Pathway DNA Replication-dependent Nucleosome Assembly Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Endothelial Tube Morphogenesis DNA Methylation On Cytosine Chromatin Silencing At RDNA Cellular Macromolecular Complex Assembly Parturition Negative Regulation Of Blood Vessel Endothelial Cell Migration Tube Development Regulation Of Gene Silencing Regulation Of Activin Receptor Signaling Pathway Response To Copper Ion Chromatin Silencing Negative Regulation Of Endothelial Cell Migration Response To Hormone Pyrimidine Nucleobase Metabolic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Blood Vessel Endothelial Cell Migration DNA Metabolic Process Negative Regulation Of Epithelial Cell Migration Pyrimidine Nucleoside Biosynthetic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation DNA Methylation Protein Homotetramerization Pyrimidine Nucleoside Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA Binding DNA Modification Endothelium Development
Tagcloud ?		1alpha 2alpha catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm3a kdm4b kdm4c lysine mesylate mimic modestly o2 rnai tri