KDM6B

Description		lysine demethylase 6B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm MLL3/4 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Chromatin Organization Chromatin Remodeling Inflammatory Response Heart Development Regulation Of Gene Expression Response To Activity Hippocampus Development Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Cardiac Muscle Cell Differentiation Response To Fungicide Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis
Pathways		Oxidative Stress Induced Senescence HDMs demethylate histones Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 29782485 25429064) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: CREBBP CSNK2B H3C1 PRMT2 TK1 TSPYL2
Entrez ID		23135
HPRD ID		18983
Ensembl ID		ENSG00000132510
Uniprot IDs		O15054
PDB IDs		2XUE 2XXZ 4ASK 5FP3 5OY3 6F6D
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Protein-containing Complex Organization Protein-containing Complex Assembly Chromatin Organization Chromatin Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Component Assembly Peptide Lactyltransferase (CoA-dependent) Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Histone H3R8 Methyltransferase Activity Nuclear Progesterone Receptor Binding DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Nucleosome Assembly Nucleosome Organization MRF Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Release From Viral Latency Thymidine Biosynthetic Process Protein-DNA Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Protein-arginine Omega-N Asymmetric Methyltransferase Activity Thymidine Metabolic Process RDNA Binding Nucleus Adiponectin-activated Signaling Pathway Nucleoplasm Protein-arginine N-methyltransferase Activity Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Peroxisome Proliferator Activated Receptor Binding Transcription Coactivator Activity N-terminal Protein Amino Acid Acetylation Chromatin Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Tube Morphogenesis Peptidyl-lysine Acetylation Pyrimidine Nucleoside Metabolic Process Regulation Of Cellular Response To Heat Protein Kinase Regulator Activity Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Acetyltransferase Activity Cellular Response To Lectin
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