KDM6B and PRMT2

Number of citations of the paper that reports this interaction (PubMedID 30224337)
114

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KDM6B	PRMT2
Description		lysine demethylase 6B	protein arginine methyltransferase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm MLL3/4 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity	Transcription Coactivator Activity Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Nuclear Estrogen Receptor Binding Nuclear Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Thyroid Hormone Receptor Binding Nuclear Androgen Receptor Binding Histone H3R8 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Chromatin Organization Chromatin Remodeling Inflammatory Response Heart Development Regulation Of Gene Expression Response To Activity Hippocampus Development Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Cardiac Muscle Cell Differentiation Response To Fungicide Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Developmental Cell Growth Negative Regulation Of Inflammatory Response Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Oxidative Stress Induced Senescence HDMs demethylate histones Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 29782485 25429064) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)	Diverticular disease ( 30177863)
Interacting Genes		6 interacting genes: CREBBP CSNK2B H3C1 PRMT2 TK1 TSPYL2	37 interacting genes: BAG6 CBLB CHEK2 CPSF7 DAZAP1 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 IQSEC2 KDM6B MYO6 NCOA1 NCOA6 PGR PRMT8 PRRC2A PSMB3 R3HDM1 RB1 RBM12 RBM22 RIPK2 RXRA SHANK1 SHANK3 SHTN1 SPAG8 THRB WASL WBP11 YLPM1 ZFP36 ZNF341 ZSWIM8
Entrez ID		23135	3275
HPRD ID		18983	09060
Ensembl ID		ENSG00000132510	ENSG00000160310
Uniprot IDs		O15054	A0A0S2Z3N3 P55345
PDB IDs		2XUE 2XXZ 4ASK 5FP3 5OY3 6F6D	1X2P
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Protein-containing Complex Organization Protein-containing Complex Assembly Chromatin Organization Chromatin Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Component Assembly Peptide Lactyltransferase (CoA-dependent) Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Histone H3R8 Methyltransferase Activity Nuclear Progesterone Receptor Binding DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Nucleosome Assembly Nucleosome Organization MRF Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Release From Viral Latency Thymidine Biosynthetic Process Protein-DNA Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Protein-arginine Omega-N Asymmetric Methyltransferase Activity Thymidine Metabolic Process RDNA Binding Nucleus Adiponectin-activated Signaling Pathway Nucleoplasm Protein-arginine N-methyltransferase Activity Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Peroxisome Proliferator Activated Receptor Binding Transcription Coactivator Activity N-terminal Protein Amino Acid Acetylation Chromatin Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Tube Morphogenesis Peptidyl-lysine Acetylation Pyrimidine Nucleoside Metabolic Process Regulation Of Cellular Response To Heat Protein Kinase Regulator Activity Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Acetyltransferase Activity Cellular Response To Lectin	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Positive Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Nucleus Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process MRNA Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Estrogen Response Element Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Dendritic Spine Morphogenesis Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Synaptic Receptor Adaptor Activity Regulation Of Transcription By RNA Polymerase II Steroid Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Dendritic Spine Organization RNA Binding Nuclear Estrogen Receptor Binding Neuron Projection Organization Postsynapse Organization Regulation Of Female Receptivity Female Mating Behavior MRNA Transcription By RNA Polymerase II
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