COL4A2 and BGN

Number of citations of the paper that reports this interaction (PubMedID 11259413)
0

Data Source:
HPRD (in vitro)

		COL4A2	BGN
Description		collagen type IV alpha 2 chain	biglycan
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Molecular Adaptor Activity	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Angiogenesis DNA-templated Transcription Response To Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Endodermal Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus	Blood Vessel Remodeling Bone Development Articular Cartilage Development
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Blood urea nitrogen levels ( 31152163) Coronary artery calcification ( 22144573) Coronary artery disease ( 29212778 33020668 32469254 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878) Fasting insulin ( 34059833) Glomerular filtration rate ( 29403010) Intake of sweets ( 31005972) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Maximum retinal arteriolar tortuosity ( 31597446) Middle temporal gyrus volume ( 31530798) Monocyte count ( 32888494) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage ( 31430377) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Retinal arteriolar tortuosity ( 31597446) Septic shock (28-day mortality) ( 32755526) Serum alkaline phosphatase levels ( 33547301) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		24 interacting genes: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TENT5A TGFBI TK1 VHL	21 interacting genes: - APOB APP BMP4 CCN4 COL18A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL6A1 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 THBS1 TNF
Entrez ID		1284	633
HPRD ID		00355	02359
Ensembl ID		ENSG00000134871	ENSG00000182492
Uniprot IDs		P08572	B4DNL4 P21810
PDB IDs		1LI1 5NAX 5NB2 6MPX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Matrix Organization Extracellular Structure Organization Protein Serine/threonine Kinase Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Binding Signaling Receptor Binding Integrin Binding Peptidase Activator Activity Heparin Binding Extracellular Space Collagen Binding Developmental Process Platelet Alpha Granule Identical Protein Binding High-density Lipoprotein Particle Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid Fibril Formation Angiogenesis Regulation Of Cell Differentiation Extracellular Exosome Calcium Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Differentiation Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development	Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Platelet-derived Growth Factor Binding Anatomical Structure Morphogenesis Collagen Trimer Animal Organ Morphogenesis Basement Membrane Extracellular Space Response To Mechanical Stimulus Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Growth Factor Stimulus Negative Regulation Of MiRNA Transcription Extracellular Matrix Assembly Cellular Response To Amino Acid Stimulus Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Growth Factor Fibrillar Collagen Trimer Developmental Process Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Fibril Organization Response To Xenobiotic Stimulus Heparin Binding Tube Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Primary MiRNA Processing Collagen Type I Trimer System Development Bone Development Regulation Of MiRNA Transcription Animal Organ Development Response To Activity Skeletal System Development Positive Regulation Of Cell Migration System Process Positive Regulation Of Cell Motility Regulation Of MiRNA Metabolic Process Positive Regulation Of Locomotion Positive Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Mononuclear Cell Migration Cell Surface Receptor Signaling Pathway
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