COL4A2 and SERPINE2

Number of citations of the paper that reports this interaction (PubMedID 8006028)
0

Data Source:
HPRD (in vivo)

		COL4A2	SERPINE2
Description		collagen type IV alpha 2 chain	serpin family E member 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Extracellular Matrix Platelet Alpha Granule Neuromuscular Junction Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Molecular Adaptor Activity	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Angiogenesis DNA-templated Transcription Response To Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Endodermal Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus	Nervous System Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Protein Processing Cerebellar Granular Layer Morphogenesis Cell Differentiation Protein Catabolic Process Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Blood urea nitrogen levels ( 31152163) Coronary artery calcification ( 22144573) Coronary artery disease ( 29212778 33020668 32469254 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878) Fasting insulin ( 34059833) Glomerular filtration rate ( 29403010) Intake of sweets ( 31005972) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Maximum retinal arteriolar tortuosity ( 31597446) Middle temporal gyrus volume ( 31530798) Monocyte count ( 32888494) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage ( 31430377) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Retinal arteriolar tortuosity ( 31597446) Septic shock (28-day mortality) ( 32755526) Serum alkaline phosphatase levels ( 33547301) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Total cholesterol levels ( 30275531) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Blood protein levels ( 30072576) Cerebrospinal T-tau levels ( 28247064) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Height ( 20881960 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Platelet-derived growth factor BB levels ( 27989323)
Interacting Genes		24 interacting genes: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TENT5A TGFBI TK1 VHL	9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ETS2 F2 FAM9B
Entrez ID		1284	5270
HPRD ID		00355	01510
Ensembl ID		ENSG00000134871	ENSG00000135919
Uniprot IDs		P08572	P07093
PDB IDs		1LI1 5NAX 5NB2 6MPX	4DY0 4DY7
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Matrix Organization Extracellular Structure Organization Protein Serine/threonine Kinase Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Binding Signaling Receptor Binding Integrin Binding Peptidase Activator Activity Heparin Binding Extracellular Space Collagen Binding Developmental Process Platelet Alpha Granule Identical Protein Binding High-density Lipoprotein Particle Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid Fibril Formation Angiogenesis Regulation Of Cell Differentiation Extracellular Exosome Calcium Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Differentiation Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Neuromuscular Junction Development Cellular Response To Amino Acid Stimulus Ectodermal Cell Fate Commitment Response To Amino Acid Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Retinal Blood Vessel Morphogenesis Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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