THY1 and HTR6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		THY1	HTR6
Description		Thy-1 cell surface antigen	5-hydroxytryptamine receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Dendrite Growth Cone Axolemma Dendrite Membrane Neuronal Cell Body Membrane Membrane Raft Extracellular Exosome Side Of Membrane Presynapse Postsynapse Glutamatergic Synapse	Plasma Membrane Cilium Membrane Dendrite Synapse
	Molecular Function	GTPase Activator Activity Integrin Binding Protein Binding GPI Anchor Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Angiogenesis Regulation Of Cell-matrix Adhesion Regulation Of Immune System Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Migration Negative Regulation Of Cell Migration Heterotypic Cell-cell Adhesion Receptor Clustering Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Retinal Cone Cell Development Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Communication Cerebral Cortex Cell Migration Positive Regulation Of Signaling Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Serotonin receptors G alpha (s) signalling events
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Refractive error ( 32231278)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		10 interacting genes: ATXN1L ATXN7 CCR8 CLK1 FYN HTR6 ITGAM ITGAV ITGB3 LCK	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		7070	3362
HPRD ID		01769	03066
Ensembl ID		ENSG00000154096	ENSG00000158748
Uniprot IDs		B0YJA4 J3QRJ3 P04216	P50406
PDB IDs			7XTB 7YS6 8JLZ
Enriched GO Terms of Interacting Partners?		Integrin Complex Heterotypic Cell-cell Adhesion Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Non-membrane Spanning Protein Tyrosine Kinase Activity CD8 Receptor Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Cell Migration Coreceptor Activity Cell Motility CD4 Receptor Binding Phospholipase Activator Activity T Cell Receptor Binding Integrin-mediated Signaling Pathway Negative Regulation Of Low-density Lipoprotein Particle Clearance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cell-matrix Adhesion Regulation Of Lipoprotein Metabolic Process External Side Of Plasma Membrane Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol 3-kinase Binding Negative Regulation Of Lipoprotein Particle Clearance Protein Tyrosine Kinase Activity Filopodium Membrane Regulation Of Low-density Lipoprotein Particle Clearance Phospholipase Binding Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Lipid Storage Fibroblast Growth Factor Binding Integrin Binding Response To Platelet-derived Growth Factor Cell-substrate Adhesion Lamellipodium Membrane Apoptotic Cell Clearance Positive Regulation Of Protein Targeting To Membrane Microvillus Membrane Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Fibronectin Binding Wound Healing, Spreading Of Cells Regulation Of Osteoblast Proliferation Extracellular Matrix Binding Regulation Of Protein Targeting To Membrane	Learning Cognition Synapse Glutamatergic Synapse Plasma Membrane Learning Or Memory Acidic Amino Acid Transport Regulation Of Protein Localization Negative Regulation Of Intracellular Transport Dendrite Negative Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Localization Regulation Of Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Lymphocyte Activation G Protein-coupled Glutamate Receptor Signaling Pathway Guanyl Nucleotide Binding Gamma-aminobutyric Acid Transport Regulation Of IRE1-mediated Unfolded Protein Response Neuronal Cell Body Regulation Of Neurogenesis Endopeptidase Regulator Activity Anatomical Structure Formation Involved In Morphogenesis Response To Alcohol Membrane Negative Regulation Of Developmental Process Presynapse Axon Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Synaptic Vesicle Recycling Regulation Of Cell Activation Ephrin Receptor Binding GTPase Activator Activity Neuron Projection Development Postsynapse Disordered Domain Specific Binding Perinuclear Region Of Cytoplasm Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Response To Singlet Oxygen Response To Acidic PH Cellular Response To Acidic PH Cellular Response To PH
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