THY1 and ITGAM

Number of citations of the paper that reports this interaction (PubMedID 15004192)
0

Data Source:
HPRD (in vitro)

		THY1	ITGAM
Description		Thy-1 cell surface antigen	integrin subunit alpha M
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Dendrite Growth Cone Axolemma Dendrite Membrane Neuronal Cell Body Membrane Membrane Raft Extracellular Exosome Side Of Membrane Presynapse Postsynapse Glutamatergic Synapse	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	GTPase Activator Activity Integrin Binding Protein Binding GPI Anchor Binding	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Signaling Receptor Activity Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Angiogenesis Regulation Of Cell-matrix Adhesion Regulation Of Immune System Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Migration Negative Regulation Of Cell Migration Heterotypic Cell-cell Adhesion Receptor Clustering Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Retinal Cone Cell Development Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion	Microglial Cell Activation Immune System Process Complement Receptor Mediated Signaling Pathway Response To Ischemia Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Metabolic Process Ectodermal Cell Differentiation Forebrain Development Response To Estradiol Positive Regulation Of Superoxide Anion Generation Heterotypic Cell-cell Adhesion Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Response To Gram-positive Bacterium Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Microglial Cell Mediated Cytotoxicity Response To Curcumin
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 24871463 32771030 28714469 27399966 26606652 26502338 18204098 23273568 21408207 19838195 19165918 18204446) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Interacting Genes		10 interacting genes: ATXN1L ATXN7 CCR8 CLK1 FYN HTR6 ITGAM ITGAV ITGB3 LCK	56 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 GPX8 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35H1 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2
Entrez ID		7070	3684
HPRD ID		01769	00411
Ensembl ID		ENSG00000154096	ENSG00000169896
Uniprot IDs		B0YJA4 J3QRJ3 P04216	P11215
PDB IDs			1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW 7AKK 7P2D 7USL 7USM 8CE6 8CE9 8VOH 8VOI
Enriched GO Terms of Interacting Partners?		Integrin Complex Heterotypic Cell-cell Adhesion Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Non-membrane Spanning Protein Tyrosine Kinase Activity CD8 Receptor Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Cell Migration Coreceptor Activity Cell Motility CD4 Receptor Binding Phospholipase Activator Activity T Cell Receptor Binding Integrin-mediated Signaling Pathway Negative Regulation Of Low-density Lipoprotein Particle Clearance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cell-matrix Adhesion Regulation Of Lipoprotein Metabolic Process External Side Of Plasma Membrane Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol 3-kinase Binding Negative Regulation Of Lipoprotein Particle Clearance Protein Tyrosine Kinase Activity Filopodium Membrane Regulation Of Low-density Lipoprotein Particle Clearance Phospholipase Binding Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Lipid Storage Fibroblast Growth Factor Binding Integrin Binding Response To Platelet-derived Growth Factor Cell-substrate Adhesion Lamellipodium Membrane Apoptotic Cell Clearance Positive Regulation Of Protein Targeting To Membrane Microvillus Membrane Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Fibronectin Binding Wound Healing, Spreading Of Cells Regulation Of Osteoblast Proliferation Extracellular Matrix Binding Regulation Of Protein Targeting To Membrane	Membrane External Side Of Plasma Membrane Regulation Of Cellular Extravasation Adhesion Of Symbiont To Host Cell Virion Attachment To Host Cell Integrin Binding Adhesion Of Symbiont To Host Positive Regulation Of Cellular Extravasation Endoplasmic Reticulum Membrane Leukocyte Migration Involved In Inflammatory Response Cell-cell Adhesion Leukocyte Cell-cell Adhesion ICAM-3 Receptor Activity Peptide Antigen Transport Cell Surface Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Apoptotic Signaling Pathway Protein Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Receptor-mediated Virion Attachment To Host Cell Heterotypic Cell-cell Adhesion Intracellular Transport Of Virus Endoplasmic Reticulum Host Cell Serine-type Endopeptidase Complex Virion Binding Plasma Membrane Cell Adhesion Complement Component C3b Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Blood Microparticle
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